Open issues on G3 neuroendocrine neoplasms: back to the future.

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Open issues on G3 neuroendocrine neoplasms: back to the future.

Endocr Relat Cancer. 2018 Apr 18;:

Authors: Zatelli MC, Guadagno E, Messina E, Lo Calzo F, Faggiano A, Colao AAL

Abstract
The recent recognition that Grade 3 (G3) neuroendocrine neoplasms (NEN) can be divided into two different categories according to the histopathological differentiation, i.e. G3 neuroendocrine tumors (NET) and G3 neuroendocrine carcinomas (NEC) has generated a lot of interest concerning not only the diagnosis, but also the differential management of such new group of NEN. However, several issues need to be fully clarified in order to put G3 NET and G3 NEC in the right place. The aim of this review is to focus on those issues that are still undetermined starting from the current knowledge, evaluating the available evidence and the possible clinical implications.

PMID: 29669844 [PubMed - as supplied by publisher]

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