Persistent high levels of miR-502-5p are associated with poor neurological outcome in patients with aneurysmal subarachnoid hemorrhage.

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Persistent high levels of miR-502-5p are associated with poor neurological outcome in patients with aneurysmal subarachnoid hemorrhage.

World Neurosurg. 2018 Apr 21;:

Authors: Sheng B, Fang X, Liu C, Wu D, Xia D, Xu S, Lai N

Abstract
OBJECTIVE: To investigate the temporal changes in miR-502-5p expression after aneurysmal subarachnoid hemorrhage (aSAH) and to find the time to peak level.
METHODS: We collected serum from patients with aSAH (n = 129) at various time points (1, 3, 7, and 14 days post-event) and healthy controls (n = 40), at the Department of Neurosurgery, the First Affiliated Hospital of Wannan Medical College, from 1 May 2015 to 31 January 2016. We measured expression levels of miR-502-5p by PCR. We used the 2-△Ct method, and calculated correlations among variables using Spearman rank correlation coefficient analysis. We used ROC curves to identify optimal levels of miR-502-5p for aSAH, and multivariate logistic regression to analyze risk factors on the modified Rankin scale (mRS). We measured miR-502-5p expression at all four time points post-aSAH.
RESULTS: Levels rose moderately from day 1 to 7, with a substantial decrease from day 7 to 14. The peak was at day 7. Multivariate logistic regression revealed that miR-502-5p at 7 days with a significant high risk for poor outcome post-aSAH.
CONCLUSIONS: Our data suggest that persistent elevated levels of miR-502-5p participate in the development of aSAH, and may help physicians to adjust therapy for aSAH.

PMID: 29689401 [PubMed - as supplied by publisher]

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