Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases.

Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases.

Oral Dis. 2018 Apr 14;:

Authors: Velliyagounder K, Bahdila D, Pawar S, Fine DH

Abstract
The oral cavity harbors different taxonomic groups, the evolutionary co-existence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions that affect the host, both locally and systemically. This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities. One of these studies is the use of the potent antimicrobial agent lactoferrin (LF), which was originally derived from the host immune system. LF is an 80-kDa glycoprotein that has a free iron-sequestration mechanism with evident antimicrobial, antitumor and immunomodulatory properties. A wide range of active peptides have been isolated from the N-terminal region of LF, which possess antimicrobial activities. In this review, we discuss the role of LF and LF-derived peptides under a heterogeneous group of oral and maxillofacial conditions, including bacterial, fungal, viral infections; head and neck cancers; xerostomia; and implantology-bone related manifestations. This article is protected by copyright. All rights reserved.

PMID: 29656422 [PubMed - as supplied by publisher]

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