AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor (EGFR)

Publication date: Available online 7 May 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Judit Fazekas-Singer, Josef Singer, Kristina M. Ilieva, Miroslawa Matz, Ina Herrmann, Edzard Spillner, Sophia N. Karagiannis, Erika Jensen-Jarolim

Teaser

Anti-cancer immunotherapies currently rely on IgG antibodies. In line with the AllergoOncology concept we provide evidence that tumor-specific IgE, alone or combined with IgG, may be superior to IgG treatment alone. The novel can225IgE-λ was made for future studies in dogs as translational model patients.


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