Associations of Dehydroepiandrosterone Sulfate with Cardiometabolic Risk Factors in Prepubertal Children.

Associations of Dehydroepiandrosterone Sulfate with Cardiometabolic Risk Factors in Prepubertal Children.

J Clin Endocrinol Metab. 2018 May 10;:

Authors: Mäntyselkä A, Lindi V, Viitasalo A, Eloranta AM, Ågren J, Väisänen S, Voutilainen R, Laitinen T, Lakka TA, Jääskeläinen J

Abstract
Context: Premature adrenarche (PA) has been associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulfate (DHEAS) concentration with other cardiometabolic risk factors are uncertain.
Objective: To examine the associations of serum DHEAS concentration with several cardiometabolic risk factors in children.
Design: Cross-sectional data from the Physical Activity and Nutrition in Children Study.
Participants: Population sample of 207 girls and 225 boys aged 7.6 ±0.4 years.
Main outcome measures: Cardiometabolic risk factors by serum DHEAS concentration.
Results: DHEAS correlated positively with body mass index standard deviation score (BMI SDS), body fat percentage, lean body mass, high-sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), when adjusted for age and sex. The associations of DHEAS with hs-CRP and ALT disappeared when adjusted also for body fat percentage. When further adjusted for birth weight SDS, DHEAS correlated negatively with low-density lipoprotein (LDL) cholesterol and LDL/high-density lipoprotein (HDL) cholesterol ratio. LDL cholesterol was lower in children with DHEAS ≥40 µg/dL than in those with <40 µg/dL, adjusted for age, sex, and body fat percentage (86.5 vs. 92.3 mg/dL, P=0.029). This association strengthened after further adjustment for birth weight SDS (85.3 vs. 92.3 mg/dL, P=0.012).
Conclusion: Higher DHEAS itself is not associated with an increased cardiometabolic risk in prepubertal children. Instead, it may be protective, evidenced by an association with lower LDL cholesterol and LDL to HDL cholesterol ratio. The increased cardiometabolic risk in PA shown in many studies may be due to low birth weight and childhood overweight associated with PA.

PMID: 29757399 [PubMed - as supplied by publisher]

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