B Nageshwari, Ramchander Merugu
Indian Journal of Cancer 2017 54(3):566-571
INTRODUCTION: Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. The myeloma cells have enhanced expression of CD138. CD138 is a transmembrane heparin sulfate glycoprotein expressed on different types of adherent and nonadherent cells.CD138 is used as a standard marker for identification of tumor cells. AIMS AND OBJECTIVES: Despite introduction of many therapeutic agents, the management of multiple myeloma (MM) remains a challenge and search for new therapeutic agents is in progress. In this study, we attempted to evaluate the effect of an alkaline phosphatase inhibitor, levamisole on expression of CD138, and level of interleukin-6 (IL-6) in human MM cell lines RPMI 8226 and U266 B1. MATERIAL AND METHODS: U266B1 and RPMI 8226 cell lines were obtained from the National Centre for Cell Sciences, Pune. Alkaline phosphatase assay, Interleukin-6 assay and CD138 expression on myeloma cells by flow cytometry were investigated when the cells were exposed to Levamisole. RESULTS: Levamisole-mediated growth inhibition of myeloma cells in vitro is associated with a loss of CD138 and increased IL-6 secretion. The increased secretion of IL-6 by myeloma cells could be an attempt to protect themselves from apoptosis. CONCLUSION: Levamisole inhibited CD138 expression and affected the levels of IL-6 in a dose-dependent manner. The results of the present study add new dimension to levamisole's mode of action as inhibitor of CD138 and IL-6 and as an antiapoptotic agent.
https://ift.tt/2x8q8Tl
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαΐου
(7473)
-
▼
Μαΐ 24
(296)
- Estradiol Dimer Inhibits Tubulin Polymerization an...
- Steroid sulfatase inhibition success and limitatio...
- Trace element contaminants in mineral fertilizers ...
- The rational design of multiple molecular module-b...
- Control of flowering and inflorescence architectur...
- X chromosome gain is related to increased androgen...
- Improved synaptic and cognitive function in aged 3...
- Improved synaptic and cognitive function in aged 3...
- Role of DOTATATE‐PET/CT in preoperative assessment...
- A Role for Hypocretin/Orexin in Metabolic and Slee...
- Aerobic Glycolysis Controls Myeloid-Derived Suppre...
- Substantial Metabolic Activity of Human Brown Adip...
- Neurosteroid pregnenolone sulfate, alone, and as a...
- Predicted reach consequences drive time course of ...
- Pretreated animal and human waste as a substantial...
- Collision of Expanding Actin Caps with Actomyosin ...
- Distant Insulin Signaling Regulates Vertebrate Pig...
- Combination of 4-hydroperoxy cyclophosphamide and ...
- Combination of TLR8 and TLR4 agonists reduces the ...
- Editorial Board
- Nurses Wanted-Almost Everywhere.
- Nutrition and Wound Healing.
- Ostomy Care.
- Simulation Training.
- Relaxing Food Restrictions on Women in Labor.
- Colorado 'Alternative to Opioids' Pilot Project Ex...
- How Media Influences Perceptions of Suicide.
- NewsCAP: Only 50% of teens with depression are dia...
- NewsCAP: E-Cigarettes pose more harm than good as ...
- Unsafe Firearm Storage in Homes with Children.
- NewsCAP: APHA unlocks free public access to articl...
- Making Hospitals Less Threatening to Patients with...
- Trump Administration Opens Division of Conscience ...
- AJN On the Cover.
- AJN On the Web.
- Therapeutic perspectives for brain metastases in n...
- Synthesis and Biological Evaluation of Irreversibl...
- Access to new highly potent antileukemia, antivira...
- Elucidating the inhibition of peptidoglycan biosyn...
- Experimental analysis of performance and emission ...
- From fish embryos to human patients: lymphangiogen...
- Total sediment transport from an urbanizing waters...
- Sleeve Gastrectomy: Metabolic Surgical Procedure o...
- The potential role of pharmacogenomics and biotran...
- Global development of the studies focused on antib...
- Editorial Board and Contents
- Perioperative high-dose-rate brachytherapy in loca...
- Is alexithymia characterised by impaired interocep...
- Examining the neural correlates of active and pass...
- An Intermediate Pluripotent State Controlled by Mi...
- Trends and mental health correlates of nonmedical ...
- Prevalence and factors associated with use of hook...
- Isolation and antimicrobial drug susceptibility pa...
- The role of gastrointestinal permeability in food ...
- High-risk drug rashes
- Subcutaneous allergen immunotherapy may be a suita...
- Dose counting and use of short-acting beta-agonist...
- Allergy and atopy from infancy to adulthood: Messa...
- Hypereosinophilic Syndrome in the Differential Dia...
- Aβ dimers induce behavioral and neurochemical defi...
- Hypereosinophilic Syndrome in the Differential Dia...
- The Amish have Decreased Asthma and Allergic Disea...
- Provider Practices in Screening for Mental Health ...
- Written by Kristen A. Feemster. Vaccines—What Ever...
- Host characteristics and dynamics of Staphylococcu...
- SIOPE – Brain tumor group consensus guideline on c...
- Efficacy of thoracic radiotherapy in patients with...
- Respiratory motion of lymph node stations in pancr...
- Local control and fracture risk following stereota...
- Can dose outside the PTV influence the risk of dis...
- Tracking tumor biology with radiomics: A systemati...
- Anal and rectal function after intensity-modulated...
- Randomized trial comparing two methods of re-irrad...
- Heart volume reduction during radiotherapy involvi...
- Regulation of the oxidative balance with coenzyme ...
- Outcomes of adjuvant treatments for resectable int...
- Physician assessed and patient reported urinary mo...
- SBRT for pancreatic cancer: In regard of Bohoudi e...
- A radiosensitivity gene signature and PD-L1 predic...
- The European Society of Gynaecological Oncology/Eu...
- Risk factors for near-miss events and safety incid...
- Radiation dose constraints for organs at risk in n...
- Quality of radiotherapy services in post-Soviet co...
- Interleukin-10 and collagen type II immunoexpressi...
- The invisible hand and EKC hypothesis: what are th...
- Removal of Cs + from aqueous solutions by perlite
- Effectiveness of tailocins produced by Pseudomonas...
- Hypothesizing the potential complications of using...
- Sudden cardiac arrest under spinal anesthesia in a...
- T-lymphocyte profiles differ between keratoacantho...
- A Cautionary Tale: A Vascular Event With Deoxychol...
- Swept-Source Optical Coherence Tomography–Supervis...
- Commentary on Swept–Source Optical Coherence Tomog...
- Association Between Sunscreen Use and Indoor Tanni...
- Modernizing the Mohs Surgery Consultation: Institu...
- Clinical Utility of Bedside Multibeam Optical Cohe...
- Combination of Melolabial Interpolation Flap and N...
- Clinico-Surgical Characteristics of Head and Neck ...
- Treatment of Previously Treated Facial Capillary M...
- Examining the Relevance to Patients of Complicatio...
-
▼
Μαΐ 24
(296)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαΐου
(7473)
-
▼
Μαΐ 24
(296)
- Estradiol Dimer Inhibits Tubulin Polymerization an...
- Steroid sulfatase inhibition success and limitatio...
- Trace element contaminants in mineral fertilizers ...
- The rational design of multiple molecular module-b...
- Control of flowering and inflorescence architectur...
- X chromosome gain is related to increased androgen...
- Improved synaptic and cognitive function in aged 3...
- Improved synaptic and cognitive function in aged 3...
- Role of DOTATATE‐PET/CT in preoperative assessment...
- A Role for Hypocretin/Orexin in Metabolic and Slee...
- Aerobic Glycolysis Controls Myeloid-Derived Suppre...
- Substantial Metabolic Activity of Human Brown Adip...
- Neurosteroid pregnenolone sulfate, alone, and as a...
- Predicted reach consequences drive time course of ...
- Pretreated animal and human waste as a substantial...
- Collision of Expanding Actin Caps with Actomyosin ...
- Distant Insulin Signaling Regulates Vertebrate Pig...
- Combination of 4-hydroperoxy cyclophosphamide and ...
- Combination of TLR8 and TLR4 agonists reduces the ...
- Editorial Board
- Nurses Wanted-Almost Everywhere.
- Nutrition and Wound Healing.
- Ostomy Care.
- Simulation Training.
- Relaxing Food Restrictions on Women in Labor.
- Colorado 'Alternative to Opioids' Pilot Project Ex...
- How Media Influences Perceptions of Suicide.
- NewsCAP: Only 50% of teens with depression are dia...
- NewsCAP: E-Cigarettes pose more harm than good as ...
- Unsafe Firearm Storage in Homes with Children.
- NewsCAP: APHA unlocks free public access to articl...
- Making Hospitals Less Threatening to Patients with...
- Trump Administration Opens Division of Conscience ...
- AJN On the Cover.
- AJN On the Web.
- Therapeutic perspectives for brain metastases in n...
- Synthesis and Biological Evaluation of Irreversibl...
- Access to new highly potent antileukemia, antivira...
- Elucidating the inhibition of peptidoglycan biosyn...
- Experimental analysis of performance and emission ...
- From fish embryos to human patients: lymphangiogen...
- Total sediment transport from an urbanizing waters...
- Sleeve Gastrectomy: Metabolic Surgical Procedure o...
- The potential role of pharmacogenomics and biotran...
- Global development of the studies focused on antib...
- Editorial Board and Contents
- Perioperative high-dose-rate brachytherapy in loca...
- Is alexithymia characterised by impaired interocep...
- Examining the neural correlates of active and pass...
- An Intermediate Pluripotent State Controlled by Mi...
- Trends and mental health correlates of nonmedical ...
- Prevalence and factors associated with use of hook...
- Isolation and antimicrobial drug susceptibility pa...
- The role of gastrointestinal permeability in food ...
- High-risk drug rashes
- Subcutaneous allergen immunotherapy may be a suita...
- Dose counting and use of short-acting beta-agonist...
- Allergy and atopy from infancy to adulthood: Messa...
- Hypereosinophilic Syndrome in the Differential Dia...
- Aβ dimers induce behavioral and neurochemical defi...
- Hypereosinophilic Syndrome in the Differential Dia...
- The Amish have Decreased Asthma and Allergic Disea...
- Provider Practices in Screening for Mental Health ...
- Written by Kristen A. Feemster. Vaccines—What Ever...
- Host characteristics and dynamics of Staphylococcu...
- SIOPE – Brain tumor group consensus guideline on c...
- Efficacy of thoracic radiotherapy in patients with...
- Respiratory motion of lymph node stations in pancr...
- Local control and fracture risk following stereota...
- Can dose outside the PTV influence the risk of dis...
- Tracking tumor biology with radiomics: A systemati...
- Anal and rectal function after intensity-modulated...
- Randomized trial comparing two methods of re-irrad...
- Heart volume reduction during radiotherapy involvi...
- Regulation of the oxidative balance with coenzyme ...
- Outcomes of adjuvant treatments for resectable int...
- Physician assessed and patient reported urinary mo...
- SBRT for pancreatic cancer: In regard of Bohoudi e...
- A radiosensitivity gene signature and PD-L1 predic...
- The European Society of Gynaecological Oncology/Eu...
- Risk factors for near-miss events and safety incid...
- Radiation dose constraints for organs at risk in n...
- Quality of radiotherapy services in post-Soviet co...
- Interleukin-10 and collagen type II immunoexpressi...
- The invisible hand and EKC hypothesis: what are th...
- Removal of Cs + from aqueous solutions by perlite
- Effectiveness of tailocins produced by Pseudomonas...
- Hypothesizing the potential complications of using...
- Sudden cardiac arrest under spinal anesthesia in a...
- T-lymphocyte profiles differ between keratoacantho...
- A Cautionary Tale: A Vascular Event With Deoxychol...
- Swept-Source Optical Coherence Tomography–Supervis...
- Commentary on Swept–Source Optical Coherence Tomog...
- Association Between Sunscreen Use and Indoor Tanni...
- Modernizing the Mohs Surgery Consultation: Institu...
- Clinical Utility of Bedside Multibeam Optical Cohe...
- Combination of Melolabial Interpolation Flap and N...
- Clinico-Surgical Characteristics of Head and Neck ...
- Treatment of Previously Treated Facial Capillary M...
- Examining the Relevance to Patients of Complicatio...
-
▼
Μαΐ 24
(296)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου