Publication date: July 2018
Source:Clinical Neurophysiology, Volume 129, Issue 7
Author(s): Malcolm Proudfoot, Freek van Ede, Andrew Quinn, Giles L. Colclough, Joanne Wuu, Kevin Talbot, Michael Benatar, Mark W. Woolrich, Anna C. Nobre, Martin R. Turner
ObjectivesThe neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typically observed in the beta-band (15–30 Hz) range during steady force production. We aimed to measure pathological alteration to CMC resulting from ALS.MethodsCMC was appraised during a forearm grip task in 17 ALS patients contrasted against age-matched healthy controls. An exploratory comparison with a group of asymptomatic ALS gene carriers and neuropathy disease mimics was also undertaken. Neural signals were acquired by whole-head magnetoencephalography and localised via structural MRI to the motor cortices.ResultsDuring light voluntary muscular contraction, beta-band CMC was significantly reduced in ALS patients compared to healthy controls. Propagation of motoric beta rhythms across the cortical hemispheres was also shown to be impaired in ALS patients. CMC was preserved in the asymptomatic gene carrier and did not distinguish ALS patients from neuropathy mimics.ConclusionFunctional connectivity metrics reveal an ALS-related decrease in both corticomuscular and interhemispheric communication during bilateral grip force production.SignificanceMEG-derived beta oscillation coupling may be a potential biomarker of motor system dysfunction in ALS, against which to measure future therapeutic efficacy.
https://ift.tt/2JaJA6u
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαΐου
(7473)
-
▼
Μαΐ 26
(279)
- Editorial Board
- Likelihood estimation of drug occupancy for brain ...
- Is the encoding of Reward Prediction Error reliabl...
- Extreme weather event may induce Microcystis bloom...
- Circulating integrin alpha4/beta7+ lymphocytes tar...
- Combination of anti-citrullinated protein antibodi...
- Circulating integrin alpha4/beta7+ lymphocytes tar...
- Combination of anti-citrullinated protein antibodi...
- Impaired spatial processing in a mouse model of fr...
- Role of Cervical Vestibular Evoked Myogenic Potent...
- Authors response to communication about mathematic...
- The increase in fiber size in male rat gastrocnemi...
- Editorial Board
- Effects of metformin on cell growth and AMPK activ...
- Estrogen-induced transcription factor EGR1 regulat...
- Molecular profiles of oxyphilic and chief cell par...
- Activation of Nrf2 might reduce oxidative stress i...
- Corticotropin releasing hormone can selectively st...
- Regulation of NADPH oxidase NOX4 by delta iodolact...
- Mathematical modeling of gonadotropin-releasing ho...
- Retraction notice to: "Role of Mammalian sirtuin 1...
- Editorial - Endocrine Tumor
- MENIN loss as a tissue-specific driver of tumorige...
- Editorial Board
- Targeting RAW 264.7 macrophages (M1 type) with Wit...
- Predicted miRNA-mRNA-mediated posttranscriptional ...
- Genomic organization and adaptive evolution of IGH...
- Pirfenidone ameliorates lipopolysaccharide-induced...
- TLR2/4 ligand-amplified liver inflammation promote...
- Polyglutamine binding protein 1 (PQBP1) inhibits i...
- Notch1 primes CD4 T cells for T helper type I diff...
- Predicted miRNA-mRNA-mediated posttranscriptional ...
- Genomic organization and adaptive evolution of IGH...
- Pirfenidone ameliorates lipopolysaccharide-induced...
- TLR2/4 ligand-amplified liver inflammation promote...
- Polyglutamine binding protein 1 (PQBP1) inhibits i...
- Notch1 primes CD4 T cells for T helper type I diff...
- Structure-based drug design to overcome species di...
- Synthesis and hybridizing properties of isoDNAs in...
- Rational design of bis-indolylmethane-oxadiazole h...
- Developing hybrid molecule therapeutics for divers...
- Cyclic biphalin analogues with a novel linker lead...
- Persistent 3′-phosphate termini and increased cyto...
- Antinuclear antibodies and cancer: A literature re...
- The unfolded protein response as a target for anti...
- Systemic therapy for intermediate and advanced hep...
- Asymptomatic Pulmonary Artery Intimal Sarcoma with...
- MEK inhibition may increase survival of NRAS-mutat...
- Overweight is associated to a better prognosis in ...
- Liver–Microbiome Axis in Health and Disease
- Workflow and efficiency in MRI-based high-dose-rat...
- Removal of heavy metals from aluminum anodic oxida...
- The possible effects of anthropogenic acoustic pol...
- Characterization of potassium hydroxide modified a...
- Zooplankton sensitivity and phytoplankton regrowth...
- Disrupting mating of Lobesia botrana using sex phe...
- Green separation and characterization of fatty aci...
- Preparation and characterization of CS/β-CD/Nano-Z...
- Long non-coding RNA CASC15 promotes tongue squamou...
- Supercritical carbon dioxide extract of Cinnamomum...
- Transition to drug co-use among adolescent cannabi...
- Perceived family relationship quality and use of p...
- Editorial Board
- Comparing intrafamilial child sexual abuse and com...
- Editorial Board
- Reduction of the molecular chaperone binding immun...
- Sublingual gland excision for the surgical managem...
- Adherence to Continuous Positive Airway Pressure t...
- The impact of nasal airflow on sinus mucosa: A rad...
- Risks and benefits of local anesthesia versus gene...
- Treatment of intravitreal bevacizumab combined wit...
- Effects of Anxiety, Language Skills, and Cultural ...
- Do Executive Function and Theory of Mind Predict P...
- Randomized phase II trial evaluating pain response...
- Evaluation of a magnetic resonance guided linear a...
- Daily IGRT for prostate cancer: Can we stop the tr...
- Growth stage and tissue specific colonization of e...
- MicroRNA-4497 functions as a tumor suppressor in l...
- Prevalence of lung cancer in Isfahan Province, Iran
- First experience of the Egyptian National Cancer I...
- Etiology and Morphogenesis of Congenital Heart Dis...
- Non-Vitamin K Antagonist Oral Anticoagulants: A Co...
- A History of Radionuclide Studies in the UK: 50th ...
- Self-Reported Population Health: An International ...
- Innovative Medicine: Basic Research and Developmen...
- AiREAS: Sustainocracy for a Healthy City: Phase 3:...
- Contemporary Bioethics: Islamic Perspective [Inter...
- Implementing and Evaluating Genomic Screening Prog...
- The Impact of Food Bioactives on Health: in vitro ...
- Fractal dimension: A complementary diagnostic indi...
- Females have stronger neurogenic response than mal...
- Systemic therapy in non-conventional cancers of th...
- Dysfunction of HPV16-specific CD8+ T cells derived...
- National treatment times in oropharyngeal cancer t...
- Smoking impact on HPV driven head and neck cancer’...
- Coexpression of p-IGF-1R and MMP-7 Modulates Panit...
- Tumor-Specific Mitochondrial DNA Variants Are Rare...
- Interrogation of ethnomedicinal plants for synthet...
- The hydro-ethanolic extract of Acacia seyal (Mimos...
- Traditional Mongolian medicine Eerdun Wurile impro...
-
▼
Μαΐ 26
(279)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Σάββατο 26 Μαΐου 2018
Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαΐου
(7473)
-
▼
Μαΐ 26
(279)
- Editorial Board
- Likelihood estimation of drug occupancy for brain ...
- Is the encoding of Reward Prediction Error reliabl...
- Extreme weather event may induce Microcystis bloom...
- Circulating integrin alpha4/beta7+ lymphocytes tar...
- Combination of anti-citrullinated protein antibodi...
- Circulating integrin alpha4/beta7+ lymphocytes tar...
- Combination of anti-citrullinated protein antibodi...
- Impaired spatial processing in a mouse model of fr...
- Role of Cervical Vestibular Evoked Myogenic Potent...
- Authors response to communication about mathematic...
- The increase in fiber size in male rat gastrocnemi...
- Editorial Board
- Effects of metformin on cell growth and AMPK activ...
- Estrogen-induced transcription factor EGR1 regulat...
- Molecular profiles of oxyphilic and chief cell par...
- Activation of Nrf2 might reduce oxidative stress i...
- Corticotropin releasing hormone can selectively st...
- Regulation of NADPH oxidase NOX4 by delta iodolact...
- Mathematical modeling of gonadotropin-releasing ho...
- Retraction notice to: "Role of Mammalian sirtuin 1...
- Editorial - Endocrine Tumor
- MENIN loss as a tissue-specific driver of tumorige...
- Editorial Board
- Targeting RAW 264.7 macrophages (M1 type) with Wit...
- Predicted miRNA-mRNA-mediated posttranscriptional ...
- Genomic organization and adaptive evolution of IGH...
- Pirfenidone ameliorates lipopolysaccharide-induced...
- TLR2/4 ligand-amplified liver inflammation promote...
- Polyglutamine binding protein 1 (PQBP1) inhibits i...
- Notch1 primes CD4 T cells for T helper type I diff...
- Predicted miRNA-mRNA-mediated posttranscriptional ...
- Genomic organization and adaptive evolution of IGH...
- Pirfenidone ameliorates lipopolysaccharide-induced...
- TLR2/4 ligand-amplified liver inflammation promote...
- Polyglutamine binding protein 1 (PQBP1) inhibits i...
- Notch1 primes CD4 T cells for T helper type I diff...
- Structure-based drug design to overcome species di...
- Synthesis and hybridizing properties of isoDNAs in...
- Rational design of bis-indolylmethane-oxadiazole h...
- Developing hybrid molecule therapeutics for divers...
- Cyclic biphalin analogues with a novel linker lead...
- Persistent 3′-phosphate termini and increased cyto...
- Antinuclear antibodies and cancer: A literature re...
- The unfolded protein response as a target for anti...
- Systemic therapy for intermediate and advanced hep...
- Asymptomatic Pulmonary Artery Intimal Sarcoma with...
- MEK inhibition may increase survival of NRAS-mutat...
- Overweight is associated to a better prognosis in ...
- Liver–Microbiome Axis in Health and Disease
- Workflow and efficiency in MRI-based high-dose-rat...
- Removal of heavy metals from aluminum anodic oxida...
- The possible effects of anthropogenic acoustic pol...
- Characterization of potassium hydroxide modified a...
- Zooplankton sensitivity and phytoplankton regrowth...
- Disrupting mating of Lobesia botrana using sex phe...
- Green separation and characterization of fatty aci...
- Preparation and characterization of CS/β-CD/Nano-Z...
- Long non-coding RNA CASC15 promotes tongue squamou...
- Supercritical carbon dioxide extract of Cinnamomum...
- Transition to drug co-use among adolescent cannabi...
- Perceived family relationship quality and use of p...
- Editorial Board
- Comparing intrafamilial child sexual abuse and com...
- Editorial Board
- Reduction of the molecular chaperone binding immun...
- Sublingual gland excision for the surgical managem...
- Adherence to Continuous Positive Airway Pressure t...
- The impact of nasal airflow on sinus mucosa: A rad...
- Risks and benefits of local anesthesia versus gene...
- Treatment of intravitreal bevacizumab combined wit...
- Effects of Anxiety, Language Skills, and Cultural ...
- Do Executive Function and Theory of Mind Predict P...
- Randomized phase II trial evaluating pain response...
- Evaluation of a magnetic resonance guided linear a...
- Daily IGRT for prostate cancer: Can we stop the tr...
- Growth stage and tissue specific colonization of e...
- MicroRNA-4497 functions as a tumor suppressor in l...
- Prevalence of lung cancer in Isfahan Province, Iran
- First experience of the Egyptian National Cancer I...
- Etiology and Morphogenesis of Congenital Heart Dis...
- Non-Vitamin K Antagonist Oral Anticoagulants: A Co...
- A History of Radionuclide Studies in the UK: 50th ...
- Self-Reported Population Health: An International ...
- Innovative Medicine: Basic Research and Developmen...
- AiREAS: Sustainocracy for a Healthy City: Phase 3:...
- Contemporary Bioethics: Islamic Perspective [Inter...
- Implementing and Evaluating Genomic Screening Prog...
- The Impact of Food Bioactives on Health: in vitro ...
- Fractal dimension: A complementary diagnostic indi...
- Females have stronger neurogenic response than mal...
- Systemic therapy in non-conventional cancers of th...
- Dysfunction of HPV16-specific CD8+ T cells derived...
- National treatment times in oropharyngeal cancer t...
- Smoking impact on HPV driven head and neck cancer’...
- Coexpression of p-IGF-1R and MMP-7 Modulates Panit...
- Tumor-Specific Mitochondrial DNA Variants Are Rare...
- Interrogation of ethnomedicinal plants for synthet...
- The hydro-ethanolic extract of Acacia seyal (Mimos...
- Traditional Mongolian medicine Eerdun Wurile impro...
-
▼
Μαΐ 26
(279)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου