Moesin Involvement in Oral Carcinogenesis of the Lower Lip.

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Moesin Involvement in Oral Carcinogenesis of the Lower Lip.

Anticancer Res. 2018 05;38(5):2755-2760

Authors: Assao A, Yoshino PM, Medeiros MCM, Carvalho AL, Soares FA, Kowalski LP, Oliveira DT

Abstract
BACKGROUND/AIM: This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients' prognosis.
MATERIALS AND METHODS: Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan-Meier and the survival curves compared using the log-rank test.
RESULTS: The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates.
CONCLUSION: Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma.

PMID: 29715096 [PubMed - in process]

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