Recent Advances in the Histopathology of Drug-Induced Liver Injury.

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Recent Advances in the Histopathology of Drug-Induced Liver Injury.

Surg Pathol Clin. 2018 Jun;11(2):297-311

Authors: Kleiner DE

Abstract
Drug-induced liver injury (DILI) is constantly changing as new drugs are approved and as new herbals and dietary supplements (HDS) reach the market. The pathologist plays a key role in the evaluation of DILI by classifying and interpreting the histologic findings considering patients' medical history and drug exposure. The liver biopsy findings may suggest alternative explanations of the injury and additional testing that should be performed to exclude non-DILI causes. Recent reports of iatrogenic liver injury are reviewed with attention to immunomodulatory and antineoplastic agents as well as reports of injury associated with HDS use.

PMID: 29751876 [PubMed - in process]

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