Renal Cell Carcinoma in one year: going inside the news of 2017

Publication date: Available online 2 May 2018
Source:Cancer Treatment Reviews
Author(s): Claudia Mosillo, Chiara Ciccarese, Davide Bimbatti, Emanuela Fantinel, Alberto Dalla Volta, Iolanda Bisogno, Ilaria Zampiva, Matteo Santoni, Francesco Massar, Matteo Brunelli, Rodolfo Montironi, Giampaolo Tortora, Roberto Iacovelli
Very interesting issues regarding RCC treatment have been raised during 2017. We analysed the main news that may potentially modified clinical practice. Conflicting data came from trials testing targeted therapies in the adjuvant setting, supporting the necessity of further investigations. One of the key goals of RCC research is focused on the first-line therapy, with particular interest focus on immunotherapy combinations. Redefine the standard of care with the aim of improving patients' survival represents an imperative need. Enhancing immunotherapy antitumor activity by combining immune checkpoint inhibitors with anti-angiogenetic therapies is a noteworthy research field, with promising results. In addiction, we analysed in the metastatic setting data about the role of cytoreductive nephrectomy and the possibility of delay the start of first-line therapy after an active surveillance period. Based on recent developments, the paper outlines future prospective of RCC research.



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