Serum CEA and CA19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.

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Serum CEA and CA19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.

Clin Lab. 2018 Mar 01;64(3):351-356

Authors: Zhai H, Huang J, Yang C, Fu Y, Yang B

Abstract
BACKGROUND: High concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were found in the serum of patients with colon cancer. We performed the present work to investigate the association between elevated levels of serum biomarkers (CEA and CA19-9) and shortened survival in patients with colon cancer.
METHODS: We examined patients who underwent colonoscopies between 2001 and 2014 and measured and analyzed the serum CEA and CA19-9 levels of 362 participants.
RESULTS: Elevated CEA concentrations were found to be associated with advanced invasion, lymph node metastasis, and short survival. Elevated CA19-9 concentrations also were associated with lymph node metastasis and short survival.
CONCLUSIONS: Elevated serum CEA or CA19-9 levels were found to be associated with shortened survival.

PMID: 29739122 [PubMed - in process]

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