Clinical implications of the FEF25-75 variability in childhood asthma,

Although forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) is one of the standard results in spirometry reports, current guidelines provide no recommendations for its use in the assessment of asthma. By contrast, forced expiratory volume in the first second (FEV1) is recommended as a principle spirometric parameter to assess airflow limitation by these guidelines. However, FEF25-75 was shown to be more sensitive indicator of symptomatic asthma than FEV1 in children1,2 and better correlated with air trapping in asthmatic subjects than FEV1.

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