Hymenoptera Venom Immunotherapy: Past, Present, and Future

We have learned a great deal about Hymenoptera immunotherapy since 1925 when Dr. Braun first reported the effective use of immunotherapy in a bee allergic patient. In his report, he described snipping off the posterior 1/8 inch of the body then grinding it up, extracting it in saline, and filtering the solution, demonstrating a positive skin test response and then using the same material to perform immunotherapy1. A plethora of publications in the 40 years after that first report reinforced the efficacy of whole body extract for immunotherapy to Hymenoptera.

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