Publication date: Available online 11 June 2018
Source:European Journal of Surgical Oncology
Author(s): Shu-Fang Huang, Ti-Hsuan Chien, Wen-Liang Fang, Frank Wang, Chun-Yi Tsai, Jun-Te Hsu, Chun-Nan Yeh, Tse-Ching Chen, Ren-Chin Wu, Cheng-Tang Chiu, Ta-Sen Yeh
BackgroundThe 8th edition of AJCC gastric cancer pathological staging system (AJCC8) derived from the IGCA database needs an external validated in cohorts with higher proportion of advanced disease.Patients and methodsA total of 5,386 gastric cancer patients treated at Chang Gung Memorial Hospital (CGMH) and Veteran General Hospital in Taipei (TVGH) were enrolled. Clinicopathological data of the IGCA series and the CGMH/TVGH cohort were compared. Cumulative survival curves of the CGMH/TVGH cohort as stratified by the AJCC7 and the AJCC8 were compared. Lymph node ratio (LNR) was analyzed in patients with N3b disease.ResultsPatients in the CGMH/TVGH cohort were older and had more advanced tumor stage (stage III, 49% versus 26%, p<0.001) than those in the IGCA cohort. The median survival of stages IIIA, IIIB, and IIIC as defined by the AJCC 8 were 49, 27 and 15 months, respectively, with narrower 95% confidence intervals, in comparison with 62, 30 and 18 months, respectively, as defined by the AJCC7. The AJCC8 exhibited better homogeneity within stages and discriminatory ability between stages, compared to the AJCC7. Six hundred and four patients with N3b disease were stratified by LNR into three subgroups, and their median survival were 31, 17, and 11 months, respectively (p<0.001). LNR further appeared as a powerful outcome predictor of N3b disease (HR, 3.1).ConclusionThe AJCC8 performs well in patients with high proportion of advanced gastric cancer. We recommend that LNR is a supplementary prognostic indicator for N3b disease.
https://ift.tt/2JuJAPM
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Τρίτη 12 Ιουνίου 2018
The 8th edition American Joint Committee on gastric cancer pathological staging classification performs well in a population with high proportion of locally advanced disease
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- Fast Compensatory Functional Network Changes Cause...
- Analysis of factors associated with cedar pollen s...
- Antiangiogenic therapy: markers of response, “norm...
- PCBs risk evaluation, environmental protection, an...
- Nonlinear effects of caffeine on the viability, sy...
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- Theo J. Visser, PhD (September 17, 1949–March 21, ...
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- Incidence and clinical parameters associated with ...
- Radiation therapy in renal cell carcinoma
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- Data on lithofacies, sedimentology and palaeontolo...
- Students’ participation in Hult Prize and their de...
- Paleotemperature, geochemical and grain size data ...
- Geoelectrical resistivity data set for characteris...
- Survey dataset on analysis of queues in some selec...
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- Loss of Trem2 in microglia leads to widespread dis...
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- Tumor Lysis Syndrome in the 21st Century: To Recre...
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- A Rapidly Fatal Case of Low-Dose Methotrexate Toxi...
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- Biological floating bed and bio-contact oxidation ...
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- Embracing early recovery after surgery (ERAS) prot...
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- The ethical issue of “cherry picking” patients
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- Hair cross sectioning in uncombable hair syndrome:...
- Reply to comment on “Drug survival of apremilast f...
- Health-related quality of life in patients with ma...
- Idelalisib in a patient with refractory Waldenströ...
- Antibiotic resistance genes in China: occurrence, ...
- Response to Alongi et al.
- Hematologic variables associated with brain failur...
- Artificial intelligence in radiation oncology: A s...
- High-risk Staphylococcus aureus transmission in th...
- The relationship between physical activity, appeti...
- Measuring the meat paradox: How ambivalence toward...
- Role of sublingual immunotherapy in the treatment ...
- Nasal physiology: improving our understanding in t...
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- Mucus T helper 2 biomarkers predict chronic rhinos...
- Accessory maxillary ostium repair using middle tur...
- Size of septectomy does not affect distribution of...
- New observations regarding Helicobacter pylori and...
- New observations regarding Helicobacter pylori and...
- Circulating human papillomavirus DNA as a surveill...
- Cochlear implantation using a custom guide cathete...
- Intralesional steroid injection as an alternative ...
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- Spatial distribution and ecological risk assessmen...
- Antiangiogenic therapy: markers of response, “norm...
- Scleroderma‐like skin changes induced by checkpoin...
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- The ethical issue of “cherry picking” patients
- Epidemiology of Staphylococcal Scalded Skin Syndro...
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