Association between Mismatch Negativity and Voxel-Based Brain Volume in Schizophrenia

Publication date: Available online 3 July 2018
Source:Clinical Neurophysiology
Author(s): Wei-Lieh Huang, Chao-Yu Liu, Chih-Min Liu, Hon-Man Liu, Chung-Yi Yang, Tzung-Jeng Hwang, Ming H. Hsieh, Hai-Gwo Hwu
ObjectiveThis study aimed to investigate the association between mismatch negativity (MMN) and volumes of several brain regions measured using a semi-automated method in patients with schizophrenia and healthy controls.MethodsMMN in response to duration deviants and magnetic resonance imaging were acquired from 36 schizophrenia patients and 14 healthy controls. FreeSurfer was used for volumetric analysis. MMN amplitudes, brain volumes and their association were compared between schizophrenia and controls. Correlation analysis and multiple linear regression analysis were used to examine the correlated variables of MMN.ResultsMMN amplitude was significantly lower in the schizophrenia group. In schizophrenia, MMN was positively correlated with age and negatively correlated with left hippocampal and right pars opercularis volumes. The association between left hippocampal volume and MMN in schizophrenia remained significant after controlling for potential confounders.ConclusionsSmaller hippocampal volume may play a role in the abnormal manifestation of MMN in schizophrenia.SignificanceThe significant association between MMN and left hippocampal volume may suggest unique neurobiological contribution of hippocampus in auditory processing in schizophrenia.



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