Endogenous Bradykinin and BK1-5 during ACE Inhibitor-Associated Angioedema

Publication date: Available online 21 July 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Scott Hubers, Kevin Kohm, Shouzuo Wei, Chang Yu, Hui Nian, Ryan Grabert, Daniel J. Sexton, Nancy J. Brown

Capsule Summary

Bradykinin concentrations and the ratio of bradykinin to its stable metabolite BK1-5 (RPPGF) were significantly increased in patients presenting with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema compared to ACE inhibitor-treated controls. Cleavage of high molecular weight kininogen was not increased in patients with ACE inhibitor-associated angioedema, indicating that increased bradykinin concentrations result from decreased degradation.

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