Lessons learned from the study of human inborn errors of innate immunity

Publication date: Available online 1 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Giorgia Bucciol, Leen Moens, Barbara Bosch, Xavier Bossuyt, Jean-Laurent Casanova, Anne Puel, Isabelle Meyts

Abstract

Innate immunity contributes to host defense through all cell types and relies on their shared germline genetic background, whereas adaptive immunity operates via only three main cell types, αβ T cells, γδ T cells, and B cells, and relies on their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity often underlie infectious diseases. The range and nature of infections depend on the mutated gene, the deleteriousness of the mutation, and other ill-defined factors. Most known inborn errors of innate immunity to infection disrupt the development or function of leukocytes other than T and B cells, but a growing number of inborn errors affect cells other than circulating and tissue leukocytes. Here, we review inborn errors of innate immunity that have been recently discovered or clarified. We highlight the immunological implications of these errors.

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