Resolution of Eosinophilia and Elevated Immunoglobulin E with Ibrutinib for Chronic Lymphocytic Leukemia

Eosinophilia can be categorized as mild (500-1500 eosinophils/µL), moderate (1500-5000 eosinophils/µL), or severe (≥5000 eosinophils/µL) with hypereosinophilia referring to an eosinophil count ≥1500 eosinophils/µL.1 Rarely, eosinophilia is associated with hematologic disorders that produce eosinophilopoietic cytokines.2 We describe a case of eosinophilia and elevated IgE in a 61-year-old gentleman who was subsequently diagnosed with B-cell chronic lymphocytic leukemia (B-CLL). His eosinophilia and immunoglobulin E (IgE) levels declined significantly after initiating ibrutinib therapy for B-CLL.

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