Is small airways dysfunction related to asthma control and type 2 inflammation?

Small airways dysfunction (SAD) in persistent adult asthmatics who have a preserved forced expiratory volume in 1 second (FEV1) is related to worse asthma control.1 Impulse oscillometry (IOS) is an effort-independent test used to phenotype SAD which involves normal quiet tidal breathing.2 Peripheral airways resistance can be derived from the difference between resistance at 5 Hz and 20 Hz (R5-R20) while the area under the reactance curve (AX) reflects the peripheral lung compliance.3 In patients with moderate to severe persistent asthma, R5-R20 and AX but not spirometry were closely related to asthma control assessed by asthma control questionnaire (ACQ).

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