mTORC1 and IRS1: Another Deadly Kiss

Publication date: Available online 3 August 2018

Source: Trends in Endocrinology & Metabolism

Author(s): Amin Ardestani, Kathrin Maedler

Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic demand. In their recent study, Yoneyama et al. have identified and characterized a negative feedback loop from mTORC1 to insulin receptor substrate (IRS)1; the key component of the insulin/insulin-like growth factor (IGF) signaling pathway.

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