Temporal Variation of Staphylococcus aureus clonal complexes in Atopic Dermatitis - a follow up study.

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Temporal Variation of Staphylococcus aureus clonal complexes in Atopic Dermatitis - a follow up study.

Br J Dermatol. 2018 Aug 02;:

Authors: Clausen ML, Edslev SM, Nørreslet LB, Sørensen JA, Andersen PS, Agner T

Abstract
BACKGROUND: A strong link between disease severity and S. aureus colonization of the skin has been reported in patients with atopic dermatitis (AD). In the present study, temporal variations in S. aureus colonization and S. aureus CC-type in AD patients are examined, and linked to disease severity, skin barrier properties and filaggrin (FLG) gene mutations.
METHODS: A follow-up study of a cohort of 101 adult AD patients recruited from an outpatient clinic. Bacterial swabs were taken at baseline and at follow-up from lesional skin, non-lesional skin and nose. Swabs positive for S. aureus were characterized by spa and the respective clonal complex (CC) type assigned. Patients were characterized with respect to disease severity (SCORAD), skin barrier properties (TEWL, pH) and FLG gene mutations.
RESULTS: A total of 63 patients participated in a follow-up visit. Twenty-seven patients (42.9%) were colonized at both visits, 27 were colonized only at one visit and 9 patients (14.3%) were not colonized at either visit. Of patients colonized at both visits a total of 51.9% remained colonized with the same CC-type at follow-up. Change in CC-type was related to an increase in SCORAD of 10.7 points compared to patients who carried the same CC-type who had a reduction in SCORAD of 4.4 points. Significantly higher skin pH was found in patients colonized at both visits, while change in CC-type was not related to TEWL, pH or FLG gene mutations.
CONCLUSION: Data indicates that temporal variation in S. aureus CC-type is linked to flares of the disease. This article is protected by copyright. All rights reserved.

PMID: 30070683 [PubMed - as supplied by publisher]

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