Advances in mechanisms of allergic disease 2017

Publication date: Available online 11 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Chrysanthi Skevaki, Harald Renz

Abstract

This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; T_H2 lymphocytes; B cells; dendritic cells: microbiome and barrier function; eosinophils, mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (T_H2) as well as innate (ILC2) effector cells. New pathways of lymphocyte activation, trafficking and recruitment, and effector cell mechanisms have been discovered. The plasticity of lymphocyte effector cell responses is another area where major progress has been achieved. Accumulating evidence will influence both our understanding of allergic disease but also our efforts for allergy prevention and treatment.

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