Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus

Publication date: Available online 13 October 2018

Source: Trends in Endocrinology & Metabolism

Author(s): Rinke Stienstra, Mihai G. Netea

In addition to the impact of Bacillus Calmette–Guerin (BCG) vaccination on antimicrobial host defence, a novel study reveals beneficial effects on glycaemic control in patients with long-standing type 1 diabetes mellitus (T1DM). These effects are ascribed to an accelerated glucose consumption in immune cells due to increased glycolysis and reduced oxidative phosphorylation.

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