AbstractBackground.Zoledronic acid (ZA), a potent bisphosphonate used for treatment of bone metastasis, has high bone affinity. This post hoc analysis evaluated the effects of long‐term treatment and reduction in dosing frequency of ZA on bone saturation.Materials and Methods.Pharmacokinetic data from three independent studies, OPTIMIZE‐2 (patients receiving ≥9 doses of bisphosphonates) and two phase I studies, CZOL4460503 and CZOL4460506 (patients who were bisphosphonate naïve/bisphosphonate free for ≥1 year after previous dosing), were pooled. Serial urine and plasma samples were used as surrogate markers to determine ZA plasma area under the curve (AUC) over 6 hours (AUC0–6h) and dose excreted in urine over 6 hours (urine0–6h). Potential relationships between the number of years for which patients had been treated previously at time of study entry and AUC0–6h or urine0–6h were analyzed graphically.Results.Creatinine clearances for patients were similar across the three studies and at all time points analyzed. The levels of AUC0–6h ZA in plasma at week 0 in every (q) 4 and q12 weekly arms of OPTIMIZE‐2 were 0.366 h × mg/L and 0.397 h × mg/L compared with 0.345 h × mg/L and 0.356 h × mg/L in CZOL4460503 and CZOL4460506, respectively. In OPTIMIZE‐2, the AUC0–6h ZA plasma levels were the same (0.428 h × mg/L) at week 36 in both q4 and q12 arms. The levels of ZA urine0–6h at week 36 in OPTIMIZE‐2 (q4 and q12 week arms), CZOL4460503, and CZOL4460506 were 36.6%, 30.8%, 26.5%, and 27.3%, respectively.Conclusion.Long‐term ZA treatment may not impact bone saturation, and ZA dosing frequency does not seem to influence drug retention rates.Implications for Practice.Zoledronic acid (ZA), used along with standard antineoplastic therapy to treat bone metastases associated with solid tumors and multiple myeloma, requires frequent (every 3–4 or every 12 weeks) long‐term administration. This may result in bone saturation and subsequently lead to a higher risk of adverse events such as osteonecrosis of the jaw and atypical fractures. This post hoc analysis used surrogate markers to demonstrate that prolonged ZA administration does not cause bone saturation. Furthermore, reduction in ZA dosing frequency does not affect its retention level in bones over time. These findings will help in addressing clinicians' concerns regarding prolonged ZA administration.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Indirect Evaluation of Bone Saturation with Zoledronic Acid After Long‐Term Dosing
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- Description of a novel RyR2 mutation in a juvenile...
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- Investigation of ultra-low insertion speeds in an ...
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- Achieving Ideal Facial Appearance
- Enhanced Contouring of Local Flaps
- Correction of the Crooked Nose
- Widened Dorsum: Bony and Cartilaginous Contributions
- Surgical and Nonsurgical Techniques in Forehead Re...
- Facial Scar Improvement Procedures
- Correction of the Lower Face and Neck
- Ideal Facial Relationships and Goals
- Selecting the Best Eyelid Techniques
- Rejuvenation of the Midface
- Morin Exerts Anti-Diabetic Effects in Human HepG2 ...
- Do Hospital Doctors Screen for Diabetes?
- Indirect Evaluation of Bone Saturation with Zoledr...
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- A survey of the treatment and management of patien...
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- Sporadic case of Darier disease caused by a novel ...
- A survey of the treatment and management of patien...
- In Response
- Alteration of serum and tissue tumor necrosis fact...
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- Improvement of alopecia areata with apremilast
- Chondrodysplasia punctata (CDPX2) in a male caused...
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- Improvement of alopecia areata with apremilast
- Chondrodysplasia punctata (CDPX2) in a male caused...
- Sentinel lymph node biopsy remains the most accura...
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