Signaling lymphocyte activation molecule family in systemic lupus erythematosus

Publication date: Available online 8 November 2018

Source: Clinical Immunology

Author(s): Denis Comte, Maria P. Karampetsou, Morgane Humbel, George C. Tsokos

Abstract

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by a breakdown in immune tolerance leading to the development of auto-reactive lymphocytes and autoantibodies. Recent findings have provided new insight on the role of the signaling lymphocytic activation molecule family (SLAMF) receptors, a group of nine co-regulatory molecules involved in the activation of hematopoietic cells, and their downstream protein SLAM-associated protein (SAP), into the pathogenesis of SLE. This review summarizes the current knowledge on SLAMF in human SLE immunopathogenesis, and the importance of SLAMF molecules as new therapeutic targets.

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