MicroRNA‐184 and its lncRNA sponge uca1 are induced in wounded keratinocytes in a store‐operated calcium entry‐dependent manner

Abstract

There remains a significant need for therapeutic interventions for wound healing as the clinical and socioeconomic challenges presented by the ageing population and associated rise in non‐healing wounds persist, exerting enormous pressure on health services. MicroRNAs (miRNAs) are short ≈22 nucleotide non‐coding RNA molecules that fine‐tune gene expression by degradation of mRNA targets. Several miRNAs promote keratinocyte migration, including miR‐21, miR‐31 and miR‐132 (reviewed in ³), hence miRNA‐dependent migration is emerging as a framework for wound healing.

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