Naevoid acanthosis nigricans or RAVEN (rounded and velvety epidermal naevus) and mosaic FGFR3 and FGFR2 mutations

Abstract

we read with interest the article by Larsabal et al.¹ describing two cases of RAVEN (rounded and velvety epidermal naevus) or naevoid acanthosis nigricans (NAN) associated with mosaic p.Arg252Asn FGFR3 and p.Ser252Trp FGFR2 mutations, adding to a probable case of RAVEN/NAN with comedones linked to the previously reported p.Ser252Trp FGFR2 mutation.² In the past two years, we had the opportunity to perform molecular analysis for FGFR2 and FGFR3 in seven unrelated patients with RAVEN/NAN and wish to add our experience.

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