The Consortium for Food Allergy Research (CoFAR) The First Generation

Publication date: Available online 23 December 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Hugh A. Sampson, M Cecilia Berin, Marshall Plaut, Scott H. Sicherer, Stacie Jones, A Wesley Burks, Robert Lindblad, Donald YM. Leung, Robert A. Wood

Abstract

The Consortium for Food Allergy Research (CoFAR) was established by the The National Institute of Allergy and Infectious Diseases (NIAID) in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. The Consortium was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration, an observational study of infants with milk and egg allergy was established and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a Phase 1 study of a recombinant peanut protein vaccine. The CoFAR was renewed in 2010 for an additional 5-year period during which the initial observational study was continued, a study of eosinophilic esophagitis was initiated, and new therapeutic trials were established to study epicutaneous immunotherapy for peanut allergy and to compare the safety and efficacy of egg OIT to the ingestion of baked egg for the treatment of egg allergy. The results of these efforts will be reviewed in this Rostrum, with a brief look to the future of the Consortium.

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