Thermography: High sensitivity and specificity diagnosing contact dermatitis in patch testing

Publication date: Available online 29 December 2018

Source: Allergology International

Author(s): Florian Anzengruber, Fayez Alotaibi, Lilian S. Kaufmann, Adhideb Ghosh, Martin R. Oswald, Julia-Tatjana Maul, Barbara Meier, Lars E. French, Mathias Bonmarin, Alexander A. Navarini

Abstract

Background

Patch testing of contact allergens to diagnose allergic contact dermatitis (ACD) is a traditional, useful tool. The most important decision is the distinction between allergic and irritant reactions, as this has direct implications on diagnosis and management. Our objective was to evaluate a new method of non-contact infrared reading of patch tests. Secondary objectives included a possible correlation between the intensity of the patch test reaction and temperature change.

Methods

420 positive reactions from patients were included in our study. An independent patch test reader assessed the positive reactions and classified them as allergic (of intensity + to +++) or irritant (IR). At the same time, a forward-looking infrared (FLIR) camera attachment for an iPhone was used to acquire infrared thermal images of the patch tests, and images were analyzed using the FLIR ONE app.

Results

Allergic patch test reactions were characterized by temperature increases of 0.72 ± 0.67 °C compared to surrounding skin. Irritant reactions only resulted in 0.17 ± 0.31 °C temperature increase. The mean temperature difference between the two groups was highly significant (p < 0.0001) and therefore was used to predict the type of contact dermatitis.

Conclusions

Thermography is a reliable and effective way to distinguish between allergic and irritant contact dermatitis.

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