New Aspect of Liver IL-17+γδ T Cells

Publication date: March 2019

Source: Molecular Immunology, Volume 107

Author(s): Chen Xi, Zhenghu Jia, Wu Xiaoli, Zhao Na, Weifeng He, Jianlei Hao

Abstract

Liver is a critical organ where comprehensive immune regulation or defense occurs. γδ T cells in liver represent indispensable population and are found to be regulating a variety of diseases including autoimmunity, cancer, fibrosis, and infections. IL-17⁺ γδ T cells in liver is a functional subset which has been found to have pro-inflammatory effect or anti-infection ability. However, how their function is activated or maintained, isn't well understood. Microbiota in the intestine provide continual source of metabolites to the liver, through at least the portal vein. The interaction between intestinal microbiota and liver γδ T cells has not been well studied. Li et al found that lipid antigen derived from intestinal microbiota was presented by hepatocyte CD1d, and activated liver-resident γδ T cells and maintained the IL-17 production. Moreover, microbiota promoted NAFLD through IL-17⁺ γδ T cells. Thus, new aspect of IL-17⁺ γδ T cells in the liver was characterized.

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