Are drug intradermal tests dangerous to explore cross‐reactivity and co‐sensitization in DRESS?

Abstract

Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS) is a severe Cutaneous Adverse drug Reaction, for which allergological explorations are poorly codified.

Patch tests are usually well tolerated, and their sensitivity depends on the tested drug. Due to a potential risk of relapse during the tests, intradermal tests (IDTs) are contra‐indicated in severe cutaneous drug adverse reactions ¹. Consequently, results of IDTs in DRESS allergological work‐up have been rarely reported.

The objective of this retrospective monocentric study was to assess the value and tolerance of drug IDTs in patients who had a DRESS and negative patch tests with the same drugs.

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