Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Τετάρτη 21 Οκτωβρίου 2020

 

Efficacy of immunotherapy with PD-1 inhibitor in colorectal cancer: a meta-analysis.
Conclusion: The monotherapy anti-PD-1 inhibitors are effective in treating mCRC and could be a new option for dMMR mCRC patient in first-line treatment. PMID: 33073605 [PubMed - as supplied by publisher] (Source: Journal of Comparative Effectiveness Research)
MedWorm Cancer & Oncology Research
15h
Factors Influencing Anterior/Low Anterior Resection Syndrome after Rectal or Sigmoid Resections.
CONCLUSIONS: LARS may frequently occur in patients who had undergone rectal resection. The most important factors influencing LARS were found as proximity of anastomosis to the anal canal and creating the protective stoma. Receiving chemoradiotherapy also plays an important role in LARS. PMID: 33078605 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for...
MedWorm Cancer & Oncology Research
15h
Laparoscopic versus open transhiatal approach for adenocarcinoma of the esophagogastric junction: A systematic review and meta-analysis
Publication date: Available online 20 October 2020Source: European Journal of Surgical OncologyAuthor(s): Xiao-Dong Chen, Fu-Qian He, Mao-Shan Liao, Mi Chen (Source: European Journal of Surgical Oncology (EJSO))MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
16h
Portal Vein Reconstruction With Interposition Cryopreserved Descending Thoracic Aortic Homograft
Improvements in chemoradiation have rendered more complex pancreatic cancers involving the portomesenteric venous axis amenable to surgical resection. Portal vein reconstruction (PVR) has thus become an essential component of the overall operative approach. For significant defects requiring segmental replacement, various conduits have been proposed, but the optimal repair remains unknown. Here, we present short-term results of the largest series to date using interposition cryopreserved cadaveric...
MedWorm Cancer & Oncology Research
16h
Ann Oncol; +31 new citations
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/10/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
MedWorm Cancer & Oncology Research
16h
Proliferating Onychomatricoma. Clinical, Dermoscopical, and Pathologic Features of Onychomatricoma New Variant Resembling Onycholemmal/Squamous Cell Carcinoma
Abstract: Proliferating onychomatricoma is a new challenging variant of onychomatricoma that can clinically and histologically mimic squamous cell carcinoma/onycholemmal carcinoma. This is a retrospective case series study of the clinicopathologic and dermoscopic features of 6 patients with a pathologic diagnosis of proliferating onychomatricoma, which was conducted in the dermatology and dermatopathology departments of 2 university hospitals and a private nail's dermatology consultation. The clinical,...
MedWorm Cancer & Oncology Research
16h
Cutaneous Involvement by Pleomorphic Lobular Carcinoma of the Male Breast: An Exceptional Occurrence
No abstract available (Source: The American Journal of Dermatopathology)
MedWorm Cancer & Oncology Research
16h
An Unusual Histopathological Presentation of Epidermotropic Metastatic Pharyngeal Squamous Cell Carcinoma
We report a case of a 56-year-old white man with a history of oral squamous cell carcinoma who presented with multiple papules on the face, eyelid, and chest wall. The histopathologic examination of the skin lesions revealed nests of malignant cells with basaloid features and zones of cytoplasmic vacuolization predominantly within the dermis but focally involving the epidermis. Central necrosis, focal papilla formation, and lymph-vascular invasion were also seen. Two of these lesions, each read by...
MedWorm Cancer & Oncology Research
16h
Acquired Human Papilloma Virus Type 6–Associated Epidermodysplasia Verruciformis in a Patient With Systemic Lupus Erythematosus
This article reports a case of EV in a patient with systemic lupus erythematosus and a history of 3 years immunosuppressive methylprednisolone treatment. The microscopic features of the skin biopsy showed morphologic changes of the keratinocytes characteristic of human papilloma virus (HPV) infections and immunoreactivity to p16. HPV genotyping demonstrated the presence of HPV 6 which belongs to a low-risk mucosal HPV group and has not been reported in EV previously. The clinical recognition of EV...
MedWorm Cancer & Oncology Research
16h
Cutaneous Involvement by Mantle Cell Lymphoma: Expanding the Spectrum of Histopathologic Findings in a Series of 9 Cases
We present a single institutional series of nine patients (12 specimens) with cutaneous involvement by systemic MCL and review the clinicopathologic features. Six males and 3 females (age range 55–87 years) were included. Sites of involvement were head and neck (n = 3), trunk (n = 5), and extremities (n = 4). Histopathologically, 3 showed classic cytomorphology, 2 were blastoid, 3 pleomorphic, and 1 showed features resembling marginal zone lymphoma. Two cases presented with cutaneous lesions as the...
MedWorm Cancer & Oncology Research
16h
Metastatic Mimics of Primary Cutaneous Lesions: Averting Diagnostic Pitfalls With Significant Repercussions
Abstract: Cutaneous metastases by solid malignancies often signify advanced disease and portend severely limited survival. Appropriate diagnosis of these lesions is particularly hampered when they closely resemble primary cutaneous tumors. In this article, we present two diagnostically challenging cases of metastatic lesions to the scalp bearing striking histologic resemblance to primary cutaneous neoplasms. One case of a metastatic urothelial carcinoma showed epidermotropism as well as histologic...
MedWorm Cancer & Oncology Research
16h
CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer.
Authors: Walls GM, Oughton JB, Chalmers AJ, Brown S, Collinson F, Forster MD, Franks KN, Gilbert A, Hanna GG, Hannaway N, Harrow S, Haswell T, Hiley CT, Hinsley S, Krebs M, Murden G, Phillip R, Ryan AJ, Salem A, Sebag-Montefoire D, Shaw P, Twelves CJ, Walker K, Young RJ, Faivre-Finn C, Greystoke A Abstract Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for 'gold standard' treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform...
MedWorm Cancer & Oncology Research
16h
Robot ‐assisted Laparoscopic Partial Nephrectomy using the Selective Clamping Approach
ConclusionThe selective clamping approach is an optimal strategy during RAPN and should be adopted if possible, to avoid global renal ischemia. Meticulous dissection of the hilar vessels is essential to identify arterial branches for selective clamping. (Source: Surgical Practice)
MedWorm Cancer & Oncology Research
16h
The radiologist empowerment through virtual multidisciplinary tumor boards: The commitment of oncologic care during COVID-19 pandemic
As outbreaks surged worldwide, coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO) on March 11th, 2020. As one of Europe's most affected countries, Italy undertook tight security measures, which included massive lockdowns, social distancing and prohibition of public events. In this scenario, Italian hospitals have been reprogramming their priorities to deal with the emergency, and major resources have been concentrated on safety measures for both patients...
MedWorm Cancer & Oncology Research
16h
Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients.
Authors: Fan X, Li Y, Yi X, Chen G, Jin S, Dai Y, Cui B, Dai B, Lin H, Zhou D Abstract Aberrant methylation is a hallmark of hepatocellular carcinoma and plays an important role in tumor initiation and progression. However, the epigenome-wide methylation patterns of portal vein tumor thrombosis (PVTTs) have not been fully explored. Here, we performed epigenome-wide DNA methylation of adjacent normal tissues (ANTs), paired tumor tissues and paired PVTTs using an Infinium HumanMethylation450...
MedWorm Cancer & Oncology Research
17h
Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation.
Authors: Meyer AE, Furumo Q, Stelloh C, Minella AC, Rao S Abstract Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast cancer has been hypothesized to result in the accumulation of oncogenic transcription factors that are master...
MedWorm Cancer & Oncology Research
17h
Friends and foes: Our evolving understanding of the link between Fbxw7 and p53 in cancer.
Authors: Elizabeth Caldon C PMID: 33070871 [PubMed - in process] (Source: Neoplasia)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
17h
How the COVID-19 Pandemic Could Reshape Palliative Care Into High-Tech and High-Touch Care: An Ethics of Care Perspective
No abstract available (Source: Cancer Nursing)
MedWorm Cancer & Oncology Research
17h
Delay in the Diagnosis of Breast and Colorectal Cancer in People With Severe Mental Disorders
Conclusions Individuals with severe mental disorders showed a higher risk of being diagnosed with breast and colorectal cancers at advanced stages. Implications for Practice: Cancer screening for earlier detection and intervention in people with severe mental disorders needs improvement. Mental health nurses, screening nurses, and oncology nurses could serve an essential role in increasing the screening adherence of this group of individuals. (Source: Cancer Nursing)
MedWorm Cancer & Oncology Research
17h
Factors Associated With Uncertainty in Patients Scheduled to Undergo Hematopoietic Stem Cell Transplantation
Conclusions Uncertainty is experienced by patients with hematologic cancer, and factors associated should be recognized to diminish the negative effects produced by this. Implications for Practice This experience of uncertainty and its associated factors must be visible in patients scheduled to undergo transplantation. This allows nurses to carry out interventions that have an impact on the cognitive ability mediated by information and education. Reducing the effects that uncertainty has on...
MedWorm Cancer & Oncology Research
17h
Losing Her: Children's Reported Concerns in the First 6 Months of Their Mother's Breast Cancer Diagnosis
Conclusion All children reported illness-related concerns about which they were bothered. Even seemingly short-term treatment-related absences from the child were interpreted as difficult. Implication for Practice Findings from the current study add to nurses' awareness and knowledge about the concerns of school-aged children during their mother's initial treatment of breast cancer. Nurses are in a key position to provide services directly to the child or through the mother. (Source: Cancer...
MedWorm Cancer & Oncology Research
17h
Examining the Relationship Between Patient Fatigue-Related Symptom Clusters and Carer Depressive Symptoms in Advanced Cancer Dyads: A Secondary Analysis of a Large Hospice Data Set
Background Most symptom management takes place in the community, conducted by patient and/or informal carer dyads with guidance from clinicians. Given the prevalence of cancer, there is a critical need for examination of the impact of managing multiple symptoms, particularly those that cluster with fatigue, on informal carers. Objectives To (1) examine clustering of patient fatigue-related symptom severity and distress in individuals with cancer and (2) test the hypothesis that patient fatigue-related...
MedWorm Cancer & Oncology Research
17h
Perceived Family Impact During Children’s Hospitalization for Treatment of Acute Lymphoblastic Leukemia: A Cross-sectional Study
Conclusions Families were moderately affected by children’s hospitalizations; social functioning was most affected. Families’ perceived coping effectiveness decreased as the readmissions increased. The higher risk category a child’s diagnosis is, the longer a child’s hospitalization is, and the less perceived coping effectiveness, the higher family perceived impact. Implications for Practice The findings provide a direction for the development of family-centered supportive intervention programs....
MedWorm Cancer & Oncology Research
17h
Coping Strategies for Self-perceived Burden Among Advanced Cancer Patients
Conclusion Nurses should not only support patients’ efforts to tackle the situation by themselves, but also help the family as a whole to tackle problems together. By facilitating meaningful dialogue between family members, patients’ feelings of SPB can be alleviated. Implications for Practice Nurses should facilitate dialogue between patients and their family members in order to help them discover solutions to reduce their SPB and to find positive meanings in the caregiving-receiving situation....
MedWorm Cancer & Oncology Research
17h
Frequent Stools Were Related to Reduced Quality of Life and Capacity in Daily Activities: Weekly Observations During and After Pelvic or Abdominal Radiotherapy
Background Greater knowledge regarding stool frequency and infrequency during pelvic and abdominal irradiation is needed to accurately identify patients at risk of either. Objective To describe occurrence of frequent and infrequent stools during pelvic-abdominal radiotherapy, and to compare quality of life (QoL) and activities of daily living (ADLs) of those patients experiencing frequent stools with those of patients experiencing infrequent stools. Methods Longitudinally during radiotherapy,...
MedWorm Cancer & Oncology Research
17h
The Cancer Nurse as Primary Palliative Care Agent During COVID-19
No abstract available (Source: Cancer Nursing)
MedWorm Cancer & Oncology Research
17h
“There Is No Before Cancer… There Is Only Cancer.” Perceived Late Effects of Pediatric Cancer on Survivors
Conclusions Research on young adult survivors of pediatric cancer and the residual/late effects and emotional outcomes they experience is warranted. Longitudinal research can aid in understanding how effects develop or worsen over time. Implications for Practice The findings of this study support The Children’s Oncology Group Long-term Follow-up Guidelines for practitioners. As the frontline caring for these individuals and families, nurses’ involvement in transitional care out of treatment...
MedWorm Cancer & Oncology Research
17h
Research award
No abstract available (Source: Cancer Nursing)
MedWorm Cancer & Oncology Research
17h
Complications and Costs of Peripherally Inserted Central Venous Catheters Compared With Implantable Port Catheters for Cancer Patients: A Meta-analysis
Conclusions Implantable port catheter has advantages over PICC in reducing cancer patients’ complications and less cost in terms of long-term cancer chemotherapy. Implications for Practice In terms of safety, the results provide evidence for practitioners to choose which type of central venous catheters is better for cancer chemotherapy patients. In terms of costs, practitioners need to make decisions about which type of central venous catheters has less cost. (Source: Cancer Nursing)
MedWorm Cancer & Oncology Research
17h
The Effect of Nonpharmacological Interventions on Managing Symptom Clusters Among Cancer Patients: A Systematic Review
Conclusions While symptom cluster interventions are potentially useful in cancer care, further well-designed research is needed to test them rigorously on various types of cancer symptom clusters. Implications for Practice Nonpharmacological interventions are shown to be effective in managing cancer-associated symptom clusters and could be considered as part of the existing healthcare services for cancer patients. (Source: Cancer Nursing)MedWorm Message: If you are looking to buy something in...
MedWorm Cancer & Oncology Research
17h
Comparing the Impact of Cancer and Treatment-Related Effects on Psychological Well-being and Quality of Life Between Hong Kong Survivors of Childhood Solid Tumors and Leukemia
Conclusions Survivors of childhood solid tumors reported poorer psychological well-being and HRQOL than survivors of childhood leukemia. This vulnerable group warrants more attention and support. Implications for Practice It is vital for healthcare professionals to understand the impact of cancer and treatment-related effects in the context of different types of cancer. This will facilitate development and evaluation of appropriate psychological interventions to promote psychological well-being...
MedWorm Cancer & Oncology Research
17h
A Dimension in Recovery: Return to Working Life After Breast Cancer
Conclusions The results of the study showed that RTW involves many uncertainties, and women experience difficulties resulting from themselves, work life, and colleagues. Support from family, colleagues, and employers is an important source of motivation in women’s coping with these difficulties. In addition, RTW positively influences psychosocial well-being. Implications for Practice Health professionals should provide support as part of follow-up care regarding difficulties in the return to...
MedWorm Cancer & Oncology Research
17h
3 Dimensions of Treatment Decision Making in Adolescents and Young Adults With Cancer
Conclusions As AYAs accumulate experience in making decisions, their TDM preferences might evolve at different rates depending on whether the decisions are perceived to be minor or major. Parents played a particularly important supportive role in TDM for AYA participants. Implications for Practice Clinicians should consider the AYAs’ preferences and the role they want to assume in making different decisions in order to support and encourage involvement in their TDM and care. (Source: Cancer...
MedWorm Cancer & Oncology Research
17h
Concerns and Needs of Support Among Guardians of Children on Cancer Treatment in Dar es Salaam: A Qualitative Study
Conclusion Guardians of children with cancer experience challenges during initial stages when seeking a diagnosis and have concerns and needs related to cancer care and treatment. Implications for practice Improvements are needed regarding care at regional hospitals, the cancer diagnosis, and the recognition of early signs of cancer and quick referral to diagnostic centers, compassionate caring behaviors by healthcare workers, budgetary support from the government to meet the medication supply...
MedWorm Cancer & Oncology Research
17h
Position Statement on Cancer Nursing’s Potential to Reduce the Growing Burden of Cancer Across the World
No abstract available (Source: Cancer Nursing)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
17h
Measuring Communication Similarity Between Hospice Nurses and Cancer Caregivers Using Latent Semantic Analysis
Conclusions Effective communication is essential to optimal end-of-life care. Latent semantic analysis is a feasible and promising approach for assessing communication similarity during home hospice care. Implications for Practice Hospice nurses are at the forefront of family caregiver communication, playing a vital role in empowering caregivers to assume required patient care tasks. Communication strategies such as the use of partnering statements that increase LSA scores can be taught to hospice...
MedWorm Cancer & Oncology Research
17h
Rethinking “Patient” in Cancer Nursing Research
No abstract available (Source: Cancer Nursing)
MedWorm Cancer & Oncology Research
17h
The Association of New-Onset Atrial Fibrillation and Risk of Cancer: A Systematic Review and Meta-Analysis.
Conclusion: This meta-analysis provides evidence that NOAF is associated with increased risk of cancer. The risk of incident cancer particularly increases within 90 days after NOAF diagnosis, but not after that. PMID: 33062319 [PubMed] (Source: Cardiology Research and Practice)
MedWorm Cancer & Oncology Research
17h
Lotus petal flap and vertical rectus abdominis myocutaneous flap in vulvoperineal reconstruction: a systematic review of differences in complications.
Conclusions: Overall, the lotus petal flap has lower complication rates at both the donor and the recipient site compared with the vertical rectus abdominis muscle flap. When both options seem viable, the lotus petal flap procedure may be preferred on the basis of the reported lower complication rates. Abbreviations: APE: abdominoperineal excision; ELAPE: extra levator abdominoperineal excision; LP flap: lotus petal flap; NIH: National Institute of Health; NR: not reported; RCT: randomized controlled...
MedWorm Cancer & Oncology Research
17h
Targeted Next-Generation Sequencing of Plasma Cell-Free DNA in Korean Patients with Hepatocellular Carcinoma.
Conclusions: Our targeted DNA sequencing successfully identified low-frequency pathogenic variants in the cfDNA from HCC patients by achieving high coverage of unique molecular families. Our results support the utility of cfDNA analysis to identify somatic gene variants in HCC patients. PMID: 33063681 [PubMed - in process] (Source: Annals of Laboratory Medicine)
MedWorm Cancer & Oncology Research
18h
Genotypic and Phenotypic Characteristics of Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Korean Patients.
Conclusions: We describe the genotypic and phenotypic spectrum in a small series of Korean patients with HLRCC. Our data reveal the unique characteristics of Korean patients with HLRCC and suggest a need for establishing an optimal diagnostic approach for them. PMID: 33063682 [PubMed - in process] (Source: Annals of Laboratory Medicine)
MedWorm Cancer & Oncology Research
18h
Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.
Authors: Dong Y, Ma G, Liu Y, Lu S, Liu L Abstract The prognostic value of microvessel density (MVD) in head and neck squamous cell carcinoma (HNSCC) remains disputable. The purpose of this study was to comprehensively determine the prognostic value of MVD in HNSCC. Relevant literatures were identified using PubMed, Embase, and Cochrane Library. A meta-analysis was performed to clarify the prognostic role of MVD in HNSCC patients and different subgroups. A total of 14 eligible articles...
MedWorm Cancer & Oncology Research
18h
PD-L1 Expression Level Displays a Positive Correlation with Immune Response in Pancreatic Cancer.
Authors: Zhao L, Cao Y Abstract The expression of PD-L1 could be a novel biomarker which predicts that patients are more likely to respond to immunotherapy. Our study investigated the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3+ Treg infiltration. In addition, the relationship among clinicopathological characteristics, prognosis, PD-L1 expression levels, and FOXP3+ Treg infiltration was explored. Furthermore, the relationship between...
MedWorm Cancer & Oncology Research
18h
Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma.
Conclusions: Our study for the first time demonstrated that downregulation of SNORA71A could serve as a novel biomarker for clinical assessment and prognostic prediction of HCC patients. PMID: 33062075 [PubMed - in process] (Source: Disease Markers)
MedWorm Cancer & Oncology Research
18h
Machine Learning Algorithms for the Prediction of Central Lymph Node Metastasis in Patients With Papillary Thyroid Cancer
ConclusionsIt is feasible to develop predictive models of CLNM in PTC patients by incorporating clinical characteristics and US features. The ML algorithm may be a useful tool for the prediction of lymph node metastasis in thyroid cancer. (Source: Frontiers in Endocrinology)
MedWorm Cancer & Oncology Research
18h
A Comprehensive Analysis of MicroRNAs in Human Osteoporosis
MicroRNAs (miRNAs) are single-stranded RNA molecules that control gene expression in various processes, such as cancers, Alzheimer’s disease, and bone metabolic diseases. However, the regulatory roles of miRNAs in osteoporosis have not been systematically analyzed. Here, we performed a comprehensive analysis to identify the differentially expressed miRNAs involved in osteoporosis. MiRNAs associated with osteoporosis were collected through literature retrieval and further screened based on specific...
MedWorm Cancer & Oncology Research
18h
ABCG2 C421A polymorphisms affect exposure of the epidermal growth factor receptor inhibitor gefitinib
AbstractATP-binding castle protein G2 (ABCG2) is thought to inhibit the activities of certain gefitinib transporters, thereby affecting drug pharmacokinetics. The C421A polymorphism affects the function and expression of ABCG2 on the cell membrane. Previous studies have shown that proton-pump inhibitors (PPIs) inhibit gefitinib absorption, as well as the function of ABCG2. We evaluated the plasma concentrations of gefitinib in patients with and without the ABCG2 C421A polymorphism, who were or were...
MedWorm Cancer & Oncology Research
19h
Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation
SummaryThe attrition rate of anticancer drugs during the clinical development remains very high. Interspecies extrapolation of anticancer drug pharmacodynamics (PD) could help to bridge the gap between preclinical and clinical settings and to improve drug development. Indeed, when combined with a physiologically-based-pharmacokinetics (PBPK) approach, PD interspecies extrapolation could be a powerful tool for predicting drug behavior in clinical trials. The present study aimed to explore this field...
MedWorm Cancer & Oncology Research
19h
Real-world assessment of afatinib for patients with EGFR -positive non-small cell lung cancer
Conclusions Afatinib is effective for patients with NSCLC harboring commonEGFR mutations irrespective of their clinicopathological backgrounds. A direct comparison of afatinib and osimertinib in treatment-na ïve patients is warranted to determine the optimal standard of care. (Source: Investigational New Drugs)
MedWorm Cancer & Oncology Research
19h
A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma
Conclusion PF ‑06840003 up to 500 mg BID was generally well tolerated with evidence of a pharmacodynamic effect and durable clinical benefit in a subset of patients with recurrent malignant glioma. ClinicalTrials.gov, NCT02764151, registered April 2016. (Source: Investigational New Drugs)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
19h
Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance
SummaryPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, and most patients die within one year after diagnosis. This cancer is resistant to almost all current therapies, so there is an urgent need to identify novel druggable targets. Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that functions in carcinogenesis, but its role in PDAC is unknown. Our experiments indicated that several subtypes of PDAC cells are sensitive to USP7 inhibition. In particular, pharmaceutical...
MedWorm Cancer & Oncology Research
19h
Can artificial intelligence distinguish between malignant and benign mediastinal lymph nodes using sonographic features on EBUS images?
CONCLUSIONS: The proposed intelligent approach could be useful in making diagnoses. Further development is required to improve the diagnostic accuracy of the visual interpretation. PMID: 33054411 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
19h
Evaluation of different haematoxylin stain subtypes for the optimal microscopic interpretation of cutaneous malignancy in Mohs frozen section histological procedure.
This study aimed to determine which mordant based haematoxylin (Ehrlich's, Cole's, Mayer's, Gill's I, Gill's II, Gill's III, Weigert's, Harris' or Carazzi's) produced the most optimal morphological clarity of staining for the identification of cellular and tissue morphology of cutaneous basal cell carcinoma (BCC), as part of the Mohs procedure. MATERIAL AND METHODS: In total, 100 anonymised patient cases were selected, sectioned and stained with each haematoxylin subtype. The slides were then...
MedWorm Cancer & Oncology Research
19h
Radiation dose-escalation and dose-fractionation modulate the immune microenvironment, cancer stem cells and vasculature in experimental high-grade gliomas.
CONCLUSIONS: This study demonstrates that RT dosage and fractionation significantly influence survival, tumor immunity and GSCs in experimental HGGs. These findings should be taken into account when aiming at designing more synergistic and effective radio-immunotherapy combinations. PMID: 33056947 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgical Sciences)
MedWorm Cancer & Oncology Research
19h
Genome Medicine for Brain Tumors: Current Status and Future Perspectives.
Authors: Mukasa A Abstract As a result of rapid progress in genome medicine technologies, such as the evolution of DNA sequencing and the development of molecular targeted drugs, the era of precision cancer medicine has begun. In 2019, a nationwide genome medicine system was established and cancer gene panel sequencing began being covered by national health insurance in Japan. However, patients with brain tumors have not benefited much from genome medicine, even though gliomas contain many...
MedWorm Cancer & Oncology Research
19h
The Safety and Efficacy of Camrelizumab and Its Combination With Apatinib in Various Solid Cancers
Conclusion: Camrelizumab and its combination are tolerable and appear to be efficient in treating numerous solid cancers. The combination therapy appears to have better efficacy with durable toxicity. However, these remain to be shown in future studies. Besides, baseline lactate dehydrogenase, programmed cell death ligand 1 (PD-L1) expression, tumor mutation burden, and the incidence of reactive cutaneous capillary endothelial proliferation may be efficacy predictors and need to be clarified in further...
MedWorm Cancer & Oncology Research
19h
PD-1/PD-L1 expression in anal squamous intraepithelial lesions.
CONCLUSIONS: Anal dysplastic lesions are accompanied by an inflammatory lymphocytic infiltrate expressing CD8 and PD-1, more frequent in high-grade lesions. These results highlight the involvement of the PD-1/PD-L1 pathway in the natural history of anal dysplasia. PMID: 33062194 [PubMed] (Source: Oncotarget)
MedWorm Cancer & Oncology Research
20h
NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer.
In this study, we searched for novel targets for antibody-drug conjugate (ADC) therapy for SCLC. We identified transmembrane proteins overexpressed specifically in SCLC with little or no expression in normal tissues and decided to focus on the cell adhesion molecule neurexin-1 (NRXN1). The cell surface overexpression of NRXN1 was confirmed using flow cytometry in SCLC cell lines (SHP77 and NCI-H526). The combination of a primary anti-NRXN1 monoclonal antibody and a secondary ADC exhibited anti-tumor...
MedWorm Cancer & Oncology Research
20h
Minority MOMP: a toxic, slow demise.
Authors: Xu Y, Surman DR, Ripley RT PMID: 33062191 [PubMed] (Source: Oncotarget)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
20h
Meta-analysis of gene expression profiling reveals novel basal gene signatures in MCF-10A cells transformed with cadmium.
In this study, we determined if transformation of the MCF-10A cells with Cd2+ would have a similar effect on the expression of basal genes. The results of our study indicate that there is a decrease in expression of genes associated with keratinization and cornification and this gene signature includes the genes associated with the basal subtype of breast cancer. An analysis of human breast cancer databases indicates an increased expression of this gene signature is associated with a positive correlation...
MedWorm Cancer & Oncology Research
20h
Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential.
Authors: Lin CC, Chi JT Abstract Epithelial ovarian cancer (OVCA) is the most lethal gynecologic cancer. Current treatment for OVCA involves surgical debulking of the tumors followed by combination chemotherapies. While most patients achieve complete remission, many OVCA will recur and develop chemo-resistance. Whereas recurrent OVCA may be treated by angiogenesis inhibitors, PARP inhibitors, or immunotherapies, the clinical outcomes of recurrence OVCA are still unsatisfactory. One new...
MedWorm Cancer & Oncology Research
20h
Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.
Authors: Watson AL, Keller BJ, Williams KA, Damle NN, Finnerty SJ, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA Abstract [This corrects the article DOI: 10.18632/oncotarget.1609.]. PMID: 33062197 [PubMed] (Source: Oncotarget)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via...
MedWorm Cancer & Oncology Research
20h
Targeted lymphodepletion with a CD45-directed antibody radioconjugate as a novel conditioning regimen prior to adoptive cell therapy.
Authors: Dawicki W, Allen KJH, Garg R, Geoghegan EM, Berger MS, Ludwig DL, Dadachova E Abstract Chimeric antigen receptor (CAR) T cell therapies, and adoptive cell therapy (ACT) in general, represent one of the most promising anti-cancer strategies. Conditioning has been shown to improve the immune homeostatic environment to enable successful ACT or CAR-T engraftment and expansion in vivo following infusion, and represents potential point of intervention to decrease serious toxicities following...
MedWorm Cancer & Oncology Research
20h
Diagnostic Differences in Expert Second-Opinion Consultation Cases at a Tertiary Sarcoma Center.
We present our experience with second-opinion (consultation) cases in a specialist tertiary sarcoma center. The aim of this study was to determine areas of diagnostic difficulty in soft tissue pathology. We assessed 581 second-opinion cases which were reviewed by two experienced pathologists in a period of one year. There was 62% concordance between the original and the second-opinion diagnosis, with diagnostic discrepancy in 38%. The largest group of soft tissue neoplasms received for second opinion...
MedWorm Cancer & Oncology Research
20h
Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377.
In conclusion, circ_0072088 might be used as a diagnostic biomarker and therapeutic target for ESCC. PMID: 33061973 [PubMed] (Source: Journal of Oncology)
MedWorm Cancer & Oncology Research
20h
Safety and Efficacy of Long-Term Zoledronic Acid in Advanced Breast Cancer with Bone Metastasis in South China.
Conclusions: The extension of ZA treatment did not increase the long-term adverse events and reduced the annual incidence of SREs beyond 24 months. Although longer treatment of ZA over 24 months appeared to be safe, further prospective investigation is required. PMID: 33061970 [PubMed] (Source: Journal of Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
20h
Efficacy and Safety of First-Line Immunotherapy in Combination with Chemotherapy for Patients with Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis.
Conclusion: In the first-line setting, combining immunotherapy with chemotherapy is better than standard chemotherapy in terms of OS and PFS. Across the eligible studies, PD-L1 inhibitors might be preferred. Further explorations of more ICIs in the first-line treatment for extensive-stage SCLC patients should be needed. PMID: 33061969 [PubMed] (Source: Journal of Oncology)
MedWorm Cancer & Oncology Research
20h
Bioinformatics-Based Identification of a circRNA-miRNA-mRNA Axis in Esophageal Squamous Cell Carcinomas.
Conclusion: This study provides support for the possible mechanisms of disease progression in ESCC. PMID: 33061972 [PubMed] (Source: Journal of Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
20h
Nomograms Predict Overall Survival and Cancer-Speci fic Survival in Patients with Fibrosarcoma: A SEER-Based Study.
Conclusion: We developed the nomograms that estimated 3-year and 5-year OS and CSS. These nomograms not only have good discrimination performance and calibration but also provide patients with better clinical benefits. PMID: 33061971 [PubMed] (Source: Journal of Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
20h
Heavy Drinking Among U.S. Adults, 2018.
This report describes adult alcohol use in the United States and presents the prevalence of heavy drinking by demographic characteristics, select mental health indicators, and select measures of health care access and utilization. PMID: 33054914 [PubMed - in process] (Source: NCHS data brief)
MedWorm Cancer & Oncology Research
20h
Rates of Alcohol-induced Deaths Among Adults Aged 25 and Over in Urban and Rural Areas: United States, 2000-2018.
Authors: Spencer MR, Curtin SC, Hedegaard H Abstract Excessive alcohol consumption is a well-known risk factor for mortality and has been causally linked to many diseases, conditions and injuries, including alcohol-attributable cancer, liver cirrhosis, and alcohol poisonings (1). Alcohol-induced deaths, or deaths from dependent and nondependent use of alcohol, as well as accidental poisoning by alcohol (2), have been increasing in the United States since 1999 with differences by sex, age,...
MedWorm Cancer & Oncology Research
20h
Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia
British Journal of Cancer, Published online: 21 October 2020; doi:10.1038/s41416-020-01117-8Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia (Source: British Journal of Cancer)
MedWorm Cancer & Oncology Research
20h
Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study
Breast cancer fatigue (BCF) is a complex and multidimensional condition characterized by a persistent sense of physical and/or mental stiffness, resulting in a substantial impairment of health-related quality of life in breast cancer survivors. Aim of this prospective cohort study was to evaluate the feasibility and the effectiveness of a 4-week rehabilitation protocol on BCF, muscle mass, strength, physical performance, and quality of life in breast cancer (BC) survivors. We recruited adult BC women...
MedWorm Cancer & Oncology Research
20h
Role of Tonsillectomy in the Management of Carcinomas of Unknown Primary of the Head and Neck: A Retrospective Study Based on p16 Analysis
ConclusionThese results suggest that an extended work-up should be systematically proposed including bilateral tonsillectomy (+/- mucosectomy of the base of tongue) in SCC-CUP p16-positive patients but not in p16-negatives. (Source: Frontiers in Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
20h
A novel germline variant in RET gene resulting in an additional cysteine in a family with familial medullary thyroid carcinoma
We describe a novel c.1765A >  T variant ofRET proto-oncogene in a family with medullary thyroid carcinoma (MTC) that predicts the creation of an additional cysteine p.(Ser589Cys) in the cysteine-rich domain. In this site only three other punctual variants have been described, giving rise to extra cysteines. We have characterized the clinical phenotype of this family. The index case was a 79-year-old woman with MTC in both thyroid lobes. This variant co-segregates in this family in four affected...
MedWorm Cancer & Oncology Research
20h
ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer
ConclusionOur study suggests that ASMT regulates the circadian clock system in breast cancer and inhibition of ASMT reduces the invasiveness of triple-negative breast cancer cells by downregulating clock protein in a certain extent, indicating the potential value of ASMT as a drug target for TNBC treatment. (Source: Frontiers in Oncology)
MedWorm Cancer & Oncology Research
20h
Duality of B Cell-CXCL13 Axis in Tumor Immunology
Tumor immunity is a rapidly evolving area of research consisting of many possible permutations of immune cell tumor interactions that are dependent upon cell type, tumor type, and stage in tumor progression. At the same time, the majority of cancer immunotherapies have been focused on modulating the T cell-mediated antitumor immune response and have largely ignored the potential utility that B cells possess with respect to tumor immunity. Therefore, this motivated an exploration into the role that...
MedWorm Cancer & Oncology Research
20h
The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma
In this study, we focus on the effects of maternal nutrition during pregnancy, the effects of the bioactive components in human and bovine milk, and the environmental factors that can affect early life (i.e., farming, milk processing, and bacterial exposure), and which contribute to the epigenetic mechanisms underlying the persistent programming of immune functions and allergic diseases. This knowledge will help to improve approaches to nutrition in early life and help prevent allergies in the future....
MedWorm Cancer & Oncology Research
20h
Frequency and spectrum of mutations across 94 cancer predisposition genes in African American women with invasive breast cancer
AbstractAfrican American women are at increased risk of being diagnosed at a young age and/or with triple negative breast cancer, both factors which are included in current guidelines for identifying women who may benefit from genetic testing. Commercial breast cancer predisposition genetic panels, based largely on data derived from women of European ancestry, may not capture the full spectrum of cancer predisposition genes associated with breast cancer in African American women. Between 2001 and...
MedWorm Cancer & Oncology Research
20h
Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors
Among the areas of most impactful recent progress in immunology is the discovery of inhibitory receptors and the subsequent translation of this knowledge to the clinic. Although the original and canonical member of this family is FcγRIIB, more recent studies defined PD1 as an inhibitory receptor that constrains T cell immunity to tumors. These studies led to development of “checkpoint blockade” immunotherapies (CBT) for cancers in which PD1 interactions with its ligand are blocked. Unfortunately,...
MedWorm Cancer & Oncology Research
20h
Combination of TAS-102 and bevacizumab as third-line treatment for metastatic colorectal cancer: TAS-CC3 study
ConclusionsThis study met its primary endpoint of PFS, which is comparable to the results of the C-TASK FORCE study. The TAS-102 and bevacizumab combination has the potential to be a therapeutic option for third-line treatment of metastatic CRC. (Source: International Journal of Clinical Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm...
MedWorm Cancer & Oncology Research
20h
Preoperative Prediction Nomogram Based on Integrated Profiling for Glioblastoma Multiforme in Glioma Patients
Conclusion: In conclusion, our study showed a novel preoperative model that incorporated clinically relevant variables and imaging features with laboratory data that could be used for preoperative prediction in glioma patients, thus providing more reliable evidence for surgical decision-making. (Source: Frontiers in Oncology)
MedWorm Cancer & Oncology Research
20h
Oncological Outcomes of Robotic-Assisted Surgery With High Dissection and Selective Ligation Technique for Sigmoid Colon and Rectal Cancer
Conclusions: High dissection of the IMA and selective ligation of the major feeding vessel to the sigmoid colon or rectum can be safely performed using da Vinci Surgical System,yielding favorable clinical, and oncologic outcomes in rectal or sigmoid colon cancer treatment. (Source: Frontiers in Oncology)
MedWorm Cancer & Oncology Research
20h
A Formula to Calculate the Threshold for Radiotherapy Targets on PET Images: Simulation Study
ConclusionsThe threshold changes with tumor size, resolution of the PET system and pixel size according to certain rules. The formula to calculate the threshold could provide a method to estimate threshold to outline the radiotherapy target (tumor). (Source: Frontiers in Oncology)
MedWorm Cancer & Oncology Research
20h
The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells
Asymmetric cell division (ACD) is an important physiological event in the development of various organisms and maintenance of tissue homeostasis. ACD produces two different cells in a single cell division: a stem/progenitor cell and differentiated cell. Although the balance between self-renewal and differentiation is precisely controlled, disruptions to ACD and/or enhancements in the self-renewal division (symmetric cell division: SCD) of stem cells resulted in the formation of tumors in Drosophila...
MedWorm Cancer & Oncology Research
20h
Dual-Target Peptide-Modified Erythrocyte Membrane-Enveloped PLGA Nanoparticles for the Treatment of Glioma
Penetration of the blood–brain barrier (BBB) and the blood–brain tumor barrier (BBTB) remains a significant challenge for the delivery of drugs in the treatment of glioma. Therefore, the development of targeted preparations with the ability to penetrate the BBB and BBTB, and target gliomas, is an important approach if we are to improve the efficacy of glioma treatment. In the current study, an active targeting preparation based on PLGA nanoparticles coated with erythrocyte membranes (RBCNPs) and...
MedWorm Cancer & Oncology Research
20h
Recent Advances in Immune Cell Therapy for Glioblastoma
Glioblastoma (GBM) is the most malignant form of astrocytoma with short survival and a high recurrence rate and remains a global problem. Currently, surgery, chemotherapy, radiotherapy, and other comprehensive treatments are the main treatment modalities, but patients still have a poor prognosis mainly due to the infiltrative growth of GBM and the protective effect of the blood–brain barrier on tumor cells. Therefore, immunotherapy is expected to be a good option for GBM. In the immune system, different...
MedWorm Cancer & Oncology Research
20h
Current Perspectives on Immunotherapy in the Peri-Operative Setting of Muscle-Infiltrating Bladder Cancer
Patients with muscle-infiltrating bladder cancer (MIBC) present a high risk of postoperative recurrence and death from metastatic urothelial cancer despite surgical resection. Before the use of peri-operative chemotherapy, about half (52%) of patients undergoing radical cystectomy had had a relapse of tumor disease within 5 years of surgery. However, when peri-operative cisplatin-based chemotherapy is added to radical cystectomy for patients with MIBC it provides limited benefit in terms of survival,...
MedWorm Cancer & Oncology Research
20h
Cancers, Vol. 12, Pages 3066: Cutting the Brakes on Ras-Cytoplasmic GAPs as Targets of Inactivation in Cancer
Authors: Arianna Bellazzo Licio Collavin The Ras pathway is frequently deregulated in cancer, actively contributing to tumor development and progression. Oncogenic activation of the Ras pathway is commonly due to point mutation of one of the three Ras genes, which occurs in almost one third of human cancers. In the absence of Ras mutation, the pathway is frequently activated by alternative means, including the loss of function of Ras inhibitors. Among Ras inhibitors, the GTPase-Activating...
MedWorm Cancer & Oncology Research
20h
Characteristics and Outcomes of 35 Breast Cancer Patients Infected With COVID-19
Since December 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly engulfed the world. Cancer patients infected with COVID-19 are considered to carry higher severity of the disease and higher mortality rate than common COVID-19 patients in previous studies. However, due to the poor clinical information on COVID-19 patients with cancer, the evidences that supported this conclusion are insufficient. At present, rather limited...
MedWorm Cancer & Oncology Research
20h
How to Make an Immune System and a Foreign Host Quickly Cohabit in Peace? The Challenge of Acute Graft-Versus-Host Disease Prevention After Allogeneic Hematopoietic Cell Transplantation
Allogeneic hematopoietic cell transplantation (alloHCT) has been used as cellular immunotherapy against hematological cancers for more than six decades. Its therapeutic efficacy relies on the cytoreductive effects of the conditioning regimen but also on potent graft-versus-tumor (GVT) reactions mediated by donor-derived immune cells. However, beneficial GVT effects may be counterbalanced by acute GVHD (aGVHD), a systemic syndrome in which donor immune cells attack healthy tissues of the recipient,...
MedWorm Cancer & Oncology Research
20h
Lugol ’s Iodine-Enhanced Micro-CT: A Potential 3-D Imaging Method for Detecting Tongue Squamous Cell Carcinoma Specimens in Surgery
ConclusionsI2-IK-enhanced micro-CT could, thus, indicate the tumor margin and assist pathological sampling in patients with TSCC postoperation. (Source: Frontiers in Oncology)
MedWorm Cancer & Oncology Research
20h
Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening
Cancer cell dormancy is a common feature of human tumors and represents a major clinical barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in primary tumors or disseminated in secondary organs, may reawaken and relapse into a more aggressive disease. The mechanisms underpinning dormancy entry and exit strongly resemble those governing cancer cell stemness and include intrinsic and contextual cues. Cellular and molecular components of the tumor microenvironment...
MedWorm Cancer & Oncology Research
20h
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and other diseases. Increasing evidence has shown that TXNIP expression is low in tumors and that it may act as a tumor suppressor in various cancer types such...
MedWorm Cancer & Oncology Research
20h
The Extrinsic and Intrinsic Roles of PD-L1 and Its Receptor PD-1: Implications for Immunotherapy Treatment
Programmed death-ligand 1 (PD-L1) is an immune checkpoint inhibitor that binds to its receptor PD-1 expressed by T cells and other immune cells to regulate immune responses; ultimately preventing exacerbated activation and autoimmunity. Many tumors exploit this mechanism by overexpressing PD-L1 which often correlates with poor prognosis. Some tumors have also recently been shown to express PD-1. On tumors, PD-L1 binding to PD-1 on immune cells promotes immune evasion and tumor progression, primarily...
MedWorm Cancer & Oncology Research
20h
Metronomic Celecoxib Therapy in Clinically Available Dosage Ablates Hepatocellular Carcinoma via Suppressing Cell Invasion, Growth, and Stemness in Pre-Clinical Models
ConclusionsMetronomic Celecoxib should be investigated clinically as a chemopreventive agent for selected high-risk HCC patients (e.g., HCC patients after curative treatments). (Source: Frontiers in Oncology)
MedWorm Cancer & Oncology Research
20h
Further Understanding of High-Grade Serous Ovarian Carcinogenesis: Potential Therapeutic Targets
(Source: Cancer Management and Research)
MedWorm Cancer & Oncology Research

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