Advanced age heightens hepatic damage in a murine model of scald burn injury

paythelady.61 shared this article with you from Inoreader Advanced age heightens hepatic damage in a murine model of scald burn injury Via Journal of Trauma and Acute Care Surgery - Published Ahead-of-Print Background: Elderly burn patients exhibit a lower survival rate compared with younger counterparts. The liver is susceptible to damage after burn injury, which predisposes to poor outcomes. Lipid homeostasis and the antioxidant glutathione system play fundamental roles in preserving liver integrity. Herein, we explored changes in these major pathways associated with liver damage in the aging animals after burn injury. Methods: We compared liver enzymes, histology, lipid-peroxidation, and glutathione-metabolism profiles from young and aged female mice after a 15% total-body-surface-area burn. Mice were euthanized at 24hours after injury, and livers and serum were collected. Results: Aged burn animals exhibited elevated (p View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.