Clinical and survival analysis of nasopharyngeal carcinoma with consistently negative Epstein–Barr virus DNA

xlomafota13 shared this article with you from Inoreader Clinical and survival analysis of nasopharyngeal carcinoma with consistently negative Epstein–Barr virus DNA Via Head & Neck Abstract Background To assess the clinical and survival features of nasopharyngeal carcinoma (NPC) with consistently negative Epstein–Barr virus (EBV) DNA level. Methods Propensity score matching (PSM) method was used to create well‐balanced cohorts. Kaplan–Meier method and Cox proportional hazards models were performed to conduct survival analysis. Results Four hundred and eighty patients were enrolled. Patients with consistently negative plasma EBV DNA level had a greater chance to present a relatively earlier T and N classification compared with those with positive EBV DNA level (p < .001; p = .015). And patients with consistently negative EBV level were significantly associated with preferable 3‐year DFS (95.0% vs. 84.4%, p = .004), DMFS (98.3% vs. 89.4%, p = .009), and OS (100% vs. 97.6%, p = .004). Conclusions NPC patients with consistently negative EBV DNA level performed an earlier clinical stage and negative EBV DNA level was related to preferable survival outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.