Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis

xlomafota13 shared this article with you from Inoreader Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1017-1026. doi: 10.21873/invivo.12345. ABSTRACT BACKGROUND/AIM: High risk Human papillomavirus (hr-HPV) and smoking are independant risk factors for head and neck squamous cell carcinomas (HNSCC). While hr-HPV+ HNSCC has a better prognosis than smoking-associated HNSCC no systematic data are yet available about the combined risk. PATIENTS AND METHODS: We performed a meta-analysis to assess the overall survival of HNSCC patients relative to the hr-HPV and smoking status. A literature review up to November 2019 was conducted in PubMed and Cochrane Library using the search terms 'HPV, Smoking and HNSCC'. RESULTS: Nine out of 748 articles were included, 1,436 out of 2,080 patients were hr-HPV+ The prevalence of hr-HPV+ smokers was 36%. The meta-analysis showed a significantly better 5-year overall survival for HPV+ non-smokers compared to smokers with risk ratio of 1.94 (95% confidence intervaI=1.46-2.58). CONCLUSION: Smoking is a negative prognostic factor for overall survival in patients with hr-HPV+ HNSCC and should thus be an important part of staging and treatment. PMID:33622897 | DOI:10.21873/invivo.12345 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.