“The Pruritogenic Role of the Type 2 Immune Response in Diseases Associated with Chronic Itch”

xlomafota13 shared this article with you from Inoreader "The Pruritogenic Role of the Type 2 Immune Response in Diseases Associated with Chronic Itch" Via Experimental Dermatology Abstract While there is a vast array of etiologies that may lead to chronic pruritus, recent data suggests that many of these conditions share similar interactions between keratinocytes, nerves, and the immune system. Specifically, the type 2 immune response, including Th2 T-Cells and their related cytokines, has been noted to play a major role in the development of pruritus in a variety of itchy conditions. To date, atopic dermatitis is the most striking example of this pathogenesis. However, the body of literature supporting its role in many other itchy conditions, including other inflammatory, bullous, as well as systemic diseases, continues to grow. In addition, new treatments targeting this type 2 immune system continue to be developed and investigated. In the current review, we present the current body of literature supporting the role of the type 2 immune response in itchy conditions beyond atopic dermatitis as well as potential therapeutic options that target this pathway for chron ic itch. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.