Accuracy of cancer diagnostic probe (CDP) for intra‐surgical checking of cavity side margins in neoadjuvant breast cancer cases; A human model study

xlomafota13 shared this article with you from Inoreader Accuracy of cancer diagnostic probe (CDP) for intra‐surgical checking of cavity side margins in neoadjuvant breast cancer cases; A human model study Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Recently, a real-time system, named cancer diagnostic probe (CDP), has been developed to diagnose the presence of pre-neoplastic/neoplastic cells in breast cavity side margins. Detecting mechanism is real-time determination of the ROS/H2O2 released from cancer or atypical cells, through reverse Warburg effect and hypoxia glycolysis pathways. Here we designed a human model study based on real-time checking of 387 internal margins from 39 neoadjuvant breast cancer cases by CDP. The permanent pathology results of tested lesions were our gold standard to evaluate CDP scoring. CDP results were compared with permanent pathology of tumor side margins (as a conventional margin evaluation procedure). Results showed that the sensitivity of CDP in scoring the cavity side margins of those cases is 91%. 18 involved internal margins which had been detected by CDP were declared as free margins in pathology section of tumor side samples. Just 5 involve d internal margins were missed by CDP. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.