Association between obesity and iron deficiency (Review)

xlomafota13 shared this article with you from Inoreader Association between obesity and iron deficiency (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1268. doi: 10.3892/etm.2021.10703. Epub 2021 Sep 7. ABSTRACT Obesity is a risk factor for several comorbidities and complications, including iron deficiency anemia. Iron deficiency anemia is a serious global public health problem, with a worldwide prevalence. The high prevalence of obesity in combination with iron deficiency incidence observed in different age and sex categories suggests an association between obesity and iron status. Obesity may disrupt iron homeostasis, resulting in iron deficiency anemia. The association between obesity and iron deficiency may be due to increased hepcidin levels mediated by chronic inflammation. Hepcidin is a small peptide hormone that functions as a negative regulator of intestinal iron absorption. Significant body weight loss in overweight and obese individuals decreases chronic inflammation and serum hepcidin levels, resulting in improved iron status due to increased iron absorption. However, further randomized controlled trials are required to confirm this effect. PMID:34594405 | PMC:PMC8456489 | DOI:10.3892/etm.2021.10703 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.