A novel antimicrobial peptide derived from human BPIFA1 protein protects against < em > Candida albicans < /em > infection

alwin shared this article with you from Inoreader A novel antimicrobial peptide derived from human BPIFA1 protein protects against < em > Candida albicans < /em > infection Via Innate Immunity Innate Immun. 2022 Feb 24:17534259221080543. doi: 10.1177/17534259221080543. Online ahead of print.ABSTRACTBactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is an innate immunity defense protein. Our previous studies proved its antibacterial and antiviral effects, but its role in fungi remains unknown. The study aimed to identify antifungal peptides (AFP) derived from BPIFA1, and three antimicrobial peptides (AMP1-3) were designed. The antifungal effects were proved by growth inhibition assay. AMP3 activity was confirmed by germ tube growth experiment and XTT assay. Its effects on cell wall and membrane of Candida albicans were assessed by tannic acid and Annexin V-FITC/PI double staining, respectively. Additionally, scanning electron microscope (SEM) and tra... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.