Antiviral activities of Polygonum Perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus

alexandrossfakianakis shared this article with you from Inoreader Antiviral activities of Polygonum Perfoliatum L. extract and related phenolic acid constituents against hepatitis B virus via Journal of Medical Virology Abstract Chronic hepatitis B virus (HBV) infection is an important public health problem. Polygonum perfoliatum L. is a traditional medicinal herb and has been reported having pharmacological activities such as anti-inflammatory, antibacterial and antiviral. In this study, the antiviral activities and mechanisms of Polygonum perfoliatum L. extract against HBV and the effective components were investigated. The results showed that, the total extract of Polygonum perfoliatum L. reduced the levels of HBV e antigen (HBeAg) secretion and the viral covalently closed circular DNA (CCC DNA) formation, but had little or no negative effects on viral capsid assembly and pregenomic RNA (pgRNA) packaging. Further fractionation showed that the water extract fraction exerted comparable anti-HBV activities with the total extract, especially in inhibiting the CCC DNA formation and HBeAg production, indicating that the effective antiviral components are mainly dis tributed in this fraction. Further study showed that the phenolic acids constituents, protocatechuic acid and gallic acid, but not ethyl caffeate, which are reported enriched in the water extract fraction, showed strong anti-HBV activities in inhibiting viral core DNA synthesis, CCC DNA formation and HBeAg production. These results suggested that the Polygonum perfoliatum L. total extract and the related phenolic acids like protocatechuic acid and gallic acid could inhibit HBV replication and also indicated the potential utility of Polygonum perfoliatum L. and related constituents as sources of novel antivirals against HBV. This article is protected by copyright. All rights reserved. View on Web

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