Cytokine expression pattern in bone marrow microenvironment after allogeneic stem cell transplantation in primary myelofibrosis.

Cytokine expression pattern in bone marrow microenvironment after allogeneic stem cell transplantation in primary myelofibrosis.

Biol Blood Marrow Transplant. 2015 Dec 18;

Authors: Hussein K, Stucki-Koch A, Alchalby H, Triviai I, Kröger N, Kreipe H

Abstract
The only curative therapy for primary myelofibrosis (PMF) is allogeneic stem cell transplantation (ASCT). However, although we know that patients can benefit from ASCT, we do not know the changes of the expression profile of cytokines and matrix modulation factors. In this first systematic analysis, we evaluated the expression profile of 103 factors before and after transplantation in order to identify potential biomarkers. The expression of fibrosis, inflammation and angiogenesis-associated genes were analysed in a total of 42 bone marrow biopsies: PMF patients (n=14) before and after ASCT and, for control purposes, post-ASCT multiple myeloma cases (n=14) and non-neoplastic haematopoiesis (n=10). In post-ASCT PMF cases, decreased expression of tissue inhibitor of metalloproteinases (TIMP) and platelet-derived growth factor alpha (PDGFA) correlated with bone marrow remodelling and haematological remission. Expression of several other matrix factors remained at high levels and now could contribute to post-ASCT remodelling. This is the first systematic analysis of cytokine expression in post-ASCT PMF bone marrow which shows that normalisation of bone marrow microenvironment is paralleled by decreased TIMP and PDGFA expression.

PMID: 26708839 [PubMed - as supplied by publisher]

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