Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults.

Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults.

J Clin Endocrinol Metab. 2015 Dec 28;:jc20153525

Authors: Rauschert S, Uhl O, Koletzko B, Kirchberg F, Mori TA, Huang RC, Beilin LJ, Hellmuth C, Oddy WH

Abstract
CONTEXT: Obesity and related diseases have become a global public health burden. Identifying biomarkers will lead to a better understanding of the underlying mechanisms associated with obesity and the pathways leading to insulin resistance (IR) and diabetes.
OBJECTIVE: This study aimed to identify lipidomic biomarkers associated with obesity and IR using plasma samples from a population-based cohort of young adults.
DESIGN AND SETTING: The Western Australian Pregnancy Cohort (Raine) Study enrolled 2900 pregnant women from 1989 to 1991. The 20yr follow-up was conducted between March 2010 and April 2012.
PARTICIPANTS: and Samples: Plasma samples from 1176 subjects aged 20 years were analysed using mass spectrometry based metabolomics.
MAIN OUTCOME MEASURES: Associations of analytes with markers of obesity and IR including BMI, waist circumference (WC), homeostasis model assessment (HOMA-IR) and insulin, were examined. Analyses were stratified by BMI and adjusted for lifestyle and other factors.
RESULTS: WC was positively associated with seven sphingomyelins and five diacyl-phosphatidylcholines and negatively associated with two lyso-phosphatidylcholines. HOMA-IR was negatively associated with two diacyl-phosphatidylcholines and positively with one lyso-phosphatidylcholine and one diacyl-phosphatidylcholine. No significant association was found in the obese/overweight group of the HOMA-IR model. In the normal weight group, one lyso-phosphatidylcholine was increased.
CONCLUSION: A possible discriminative effect of sphingomyelins, particularly those with two double bonds, and lyso-phosphatidylcholines was identified between subjects with normal weight and obesity independent of LDL-C and HDL-C concentrations. Our results suggest weight status dependent mechanisms for the development of IR with lyso-phosphatidylcholine C14:0 as a key metabolite in non-obese IR.

PMID: 26709969 [PubMed - as supplied by publisher]

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