Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice

Publication date: March 2016
Source:Journal of Functional Foods, Volume 21
Author(s): Bingxin Ma, Jing Tong, Gao Zhou, Qigui Mo, Jingsheng He, Youwei Wang
Coptis chinensis inflorescence is rich in isoquinoline alkaloids, especially berberine; these alkaloids comprise a chemical group with anti-hyperglycaemic effect. This study mainly investigated the α-amylase and α-glucosidase inhibitory activities of C. chinensis inflorescence extract (CE). The effect of CE was similar to that of acarbose. Results of 3T3-L1 preadipocyte assay showed that CE can increase glucose consumption. In addition, CE and its main alkaloids (jatrorrhizine, columbamine, epiberberine, coptisine, palmatine, and berberine) were used to ameliorate streptozotocin-induced diabetic mice. Anti-hyperglycaemic activity was realised by reducing the blood glucose level and increasing the insulin content. Furthermore, CE and its main alkaloids can relieve liver injury and lipid metabolic disturbance. Therefore, CE exerts anti-hyperglycaemic activity, and alkaloids may be an active compound group. Overall, the results provide scientific foundation for C. chinensis inflorescence as functional food to ameliorate hyperglycaemia.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OfNBAS
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfUSEK
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1N4TbSw
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZYqQqr
via IFTTT