Supplementary Motor Cortical Changes Explored by Resting-state Functional Connectivity in Brachial Plexus Injury.

Supplementary Motor Cortical Changes Explored by Resting-state Functional Connectivity in Brachial Plexus Injury.

World Neurosurg. 2015 Dec 30;

Authors: Lu Y, Liu H, Hua X, Xu WD, Xu JG, Gu YD

Abstract
OBJECTIVE: Brachial plexus injury is one of the most serious peripheral nerve injuries. However, clinical outcomes are generally unsatisfactory. It has been reported that cortical plasticity could influence the restoration of motor function. However, the neurological mechanism of BPI remains unclear, which provides a basis for further investigation. Supplementary motor area (SMA) plays an important role in the regulation of motor function. This study aims to explore SMA-whole brain functional connectivity after deafferentation of the brachial plexus.
METHODS: Sixteen BPI patients and eight healthy volunteers were recruited. The seed region was defined by a block-design fMRI program which used unilateral imaginary hand grasp motion as a task stimulus. Next, the ROI-wise functional connectivity between the predefined region and the other regions of the brain was calculated.
RESULTS: We discovered decreased ROI-wise functional connectivity between SMA and multiple brain regions including precuneus, posterior cingulum cortex and anterior cingulum cortex.
CONCLUSIONS: BPI patients showed weakened functional connectivity between hand-grasp related areas and SMA as well as multiple regions associated with motor processing or information integration A clear image of the functional status of the brain after deafferentation was provided. On the basis of this discovery, a relationship between changes in neural imaging measurements and clinical outcomes can be expected in future studies.

PMID: 26746337 [PubMed - as supplied by publisher]

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