Prognostic factors in patients with primary hemangiopericytomas of the central nervous system: a series of 103 cases at a single institution

Publication date: Available online 5 March 2016
Source:World Neurosurgery
Author(s): Hongda Zhu, Daniel Duran, Lingyang Hua, Hailiang Tang, Hong Chen, Ping Zhong, Kang Zheng, Yongfei Wang, Xiaoming Che, Weimin Bao, Yin Wang, Qing Xie, Ye Gong
ObjectiveHemangiopericytoma (HPC) is a rare mesenchymal tumor that tends to affect the central nervous system and is associated with distant metastasis and a high recurrence rate. The purpose of this study was to analyze the prognostic factors in surgically treated patients with primary HPC.MethodsAll adult patients with primary HPC of the central nervous system treated from 2001 to 2009 at our institution were reviewed in this retrospective study. Clinical information, adjuvant radiation, and expression levels of Ki-67 and p53 were correlated with patient outcomes.ResultsA total of 103 patients were included in the final analysis. The mean follow-up period was 75.9 ± 36.5 months (range, 1-165 months). There was a significant difference in progression free survival (PFS, P < 0.001) and overall survival (OS, P = 0.014) between patients who underwent gross total resection (GTR) versus subtotal resection (STR). p53 expression was found in 48.5% of patients and showed utility as an independent unfavorable prognostic factor for PFS (P = 0.006). Multivariate analysis revealed that only extent of tumor resection (P = 0.004) and p53 expression (P = 0.024) were independent prognostic factors for PFS. Adjuvant radiation was found to extend PFS only in the p53-negative expression group (P = 0.044).ConclusionsGTR significantly improves the outcome of patients with primary HPCs, while adjuvant radiation only contributes significantly to PFS in patients with negative p53 expression, and in those with incomplete resections. Extent of resection and p53 expression may serve as prognostic markers for the outcome of primary HPC patients.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/21S3pQm
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QCpnjg
via IFTTT