Targeting TNF alpha as a novel strategy to enhance CD8(+) T cell-dependent immune response in melanoma?

Targeting TNF alpha as a novel strategy to enhance CD8(+) T cell-dependent immune response in melanoma?

Oncoimmunology. 2016;5(1):e1068495

Authors: Bertrand F, Rochotte J, Colacios C, Montfort A, Andrieu-Abadie N, Levade T, Benoist H, Ségui B

Abstract
Tumor Necrosis Factor α (TNF) is a pleiotropic cytokine exhibiting a dual activity in oncoimmunology, either acting as a cytotoxic effector produced by leukocytes or behaving as an immunosuppressive molecule. We have just discovered that TNF signaling impairs the accumulation of tumor-infiltrating CD8(+) T lymphocytes in experimental melanoma.

PMID: 26942089 [PubMed - as supplied by publisher]

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