The role of molecular testing in soft tissue sarcoma diagnosis

[Comment]

What is the true fidelity of the expert human eye and brain in affirming an accurate sarcoma diagnosis? The study by Antoine Italiano and colleagues1 aims to answer this question by linking diagnoses made by sarcoma experts to molecular genetic testing done with fluorescence in-situ hybridisation (FISH), PCR, or reverse transcriptase-PCR for six soft tissue sarcoma subtypes. This level IV diagnostic and therapeutic study included 384 patients at 32 centres managed by the French Sarcoma Group. Sarcoma subtypes included dermatofibrosarcoma protuberans, dedifferentiated liposarcoma, Ewing's sarcoma, synovial sarcoma, alveolar rhabdomyosarcoma, and myxoid or round cell liposarcoma.

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