Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication: Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability,...
Major Changes in Systemic Therapy for Advanced Melanoma: Over the past 5 years, a host of new agents have radically changed the therapeutic landscape in advanced melanoma; gone are the days when the only active agents were interferon and dacarbazine. Nearly 25 years ago, few patients with stage IV melanoma...
Frizzled with age: An opportunity for "gerontological" medicine: Abstract Cancer shows a strong association with aging and prognosis in aged individuals is usually poor. A widely accepted paradigm attributes this phenomenon to the accumulation of oncogenic mutations over time. While independently...
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma: Background Historically leptomeningeal metastases (LM) from melanoma have a poor prognosis, with a median survival of only 2 months despite treatment. Targeted therapy and immune checkpoint inhibitors are promising new...
Frizzled with age: An opportunity for "gerontological" medicine: Abstract Cancer shows a strong association with aging and prognosis in aged individuals is usually poor. A widely accepted paradigm attributes this phenomenon to the accumulation of oncogenic mutations over time. While independently...
Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol: Summary Rhododendrol is a phenolic compound that shows a tyrosinase-dependent toxicity for melanocytes and occasionally induces a vitiligo-like skin depigmentation. The post-tyrosinase mechanisms determining...
Acute renal allograft rejection after immune checkpoint inhibitor therapy for metastatic melanoma: Immune checkpoint inhibitors such as ipilimumab and nivolumab improve survival in patients with advanced melanoma and are increasingly available to clinicians for use in the clinic. Their safety in organ...
The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma: from Melanoma2 via ola Kala on Inoreader via IFTTT
Incidence and prognostic impact of other cancers in a population of long-term survivors of chronic lymphocytic leukemia: Background Information on the impact of other cancers (OCs) in long-term survivors (LTSs) of chronic lymphocytic leukemia (CLL) is limited. Patients and methods Patients with...
Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion: Publication date: August 2016Source:Biomedicine & Pharmacotherapy, Volume 82 Author(s): Tinghong Ye, Shirui Zhu, Yongxia Zhu, Qiang Feng, Bing He, Yiong Xiong,...
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