Association between seasonal factors and multiple sclerosis: Abstract Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system. MS is causing progressive and relapsing neurological disability, due to demyelination and axonal damage. The etiopathogenesis of...
The hidden impact of a healthy-worker effect on the results of the Diesel Exhaust in Miners Study: from Cancer via ola Kala on Inoreader via IFTTT
Serum magnesium and risk of new onset heart failure in men: the Kuopio Ischemic Heart Disease Study: Abstract Serum magnesium is an essential intracellular cation involved in processes that regulate cardiovascular function and has been linked to the risk of several cardiovascular disease outcomes....
Survival Disparities Identified in Young African Americans with Colorectal Cancer: African Americans who are diagnosed with colorectal cancer at a young age have significantly worse survival rates than young white patients, according to a new study. The disparity was found even among those who were...
Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen: Abstract Background Recruitment of cofactors in the interaction of the androgen receptor (AR) and AR ligands plays a critical role in determining androgenic/antiandrogenic...
Characterisation of the DNA sequence specificity, cellular toxicity and cross-linking properties of novel bispyridine-based dinuclear platinum complexes: Abstract Background The anti-tumour activity of cisplatin is thought to be a result of its capacity to form DNA adducts which prevent cellular...
Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals: Abstract Purpose Xenograft studies are commonly used to assess the efficacy of new compounds and characterise their dose–response relationship. Analysis often involves...
Omental flap after pelvic exenteration for pelvic cancer: Abstract Pelvic infection is a significant clinical problem after pelvic exenteration. The clinical benefit of an omental flap in reducing the incidence of such infections is unknown. The aim of this study was to evaluate whether an omental...
Port-site metastasis after laparoscopic surgery for gastrointestinal cancer: Abstract Although the incidence of port-site metastasis after laparoscopic surgery for colorectal cancer has markedly decreased since laparoscopic colectomy was first reported in 1991, it still has not reached zero. In colorectal...
Changes in fat-soluble vitamin levels after gastrectomy for gastric cancer: Abstract Several authors have reported the relationship between gastric cancer risk and vitamins. However, there are few reports on fat-soluble vitamins after gastrectomy for gastric cancer. Fat malabsorption and suppression...
The dosimetric impact of implants on the spinal cord dose during stereotactic body radiotherapy: Abstract Background The effects of spinal implants on dose distribution have been studied for conformal treatment plans. However, the dosimetric impact of spinal implants in stereotactic body radiotherapy...
Brain metastases as site of first and isolated recurrence of breast cancer: the role of systemic therapy after local treatment: Abstract The role of systemic treatment was assessed after local therapy for breast cancer patients who developed central nervous system (CNS) metastases as a first and isolated...
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication: Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability,...
Correlation between County-Level Surgeon Density and Mortality from Colorectal Cancer: Abstract Purpose We aimed to explore the effect of county-level general surgeon (GS) and colorectal surgeon (CS) density on colorectal cancer (CRC) mortality and to identify additional county characteristics...
Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy: Abstract Chronic inflammation, typical of various diseases including cancer, is a "silent bomb within the body," leading to complications that are only evident in most cases upon their appearance, when...
Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy: Abstract Chronic inflammation, typical of various diseases including cancer, is a "silent bomb within the body," leading to complications that are only evident in most cases upon their appearance, when...
Deciphering the function of non-coding RNAs in prostate cancer: Abstract The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of...
NCCN Guidelines Update for Multiple Myeloma: The updated NCCN Guidelines for Multiple Myeloma feature several changes in the diagnosis and management of this disease. Criteria for treatment initiation have been broadened, new staging has been recommended, and new classes of agents and combinations are...
Abstracts From the NCCN 21st Annual Conference: Advancing the Standard of Cancer Care™: from Cancer via ola Kala on Inoreader via IFTTT
Evolving Use of Androgen Deprivation Therapy in Prostate Cancer Management: Since its introduction more than 70 years ago, the use of androgen deprivation therapy (ADT) for prostate cancer has evolved to become part of a multimodal management approach. In this presentation from the NCCN 21st Annual Conference,...
NCCN Evidence Blocks: NCCN has developed a series of Evidence Blocks: graphics that provide ratings for each recommended treatment regimen in terms of efficacy, toxicity, quality and consistency of the supporting data, and affordability. The NCCN Evidence Blocks are currently available in 10 tumor types...
Understanding and Utilizing Patient Preferences in Cancer Treatment Decisions: Shared decision-making is a complex endeavor that should take into account the patient's personal preferences regarding treatment options. To truly empower patients to be partners in decision-making, especially in situations...
The Role of Biosimilars: As biologics go off-patent, the field of oncology is grappling with incorporating biosimilars. These are highly similar (but not generic versions of) biologic agents, and they are approved based on showing "near fingerprint identity" in structure and potency. Their introduction...
Sex disparities in use of chemotherapy and survival in patients with advanced bladder cancer: BACKGROUND Women with advanced bladder cancer have inferior survival compared with men. However, women treated on clinical trials do not appear to have a survival disadvantage. Less frequent administration...
Mind the gap: What is driving the survival disparity between the sexes in bladder cancer?: Precis Bladder cancer is well known to preferentially afflict men. However, women are significantly more likely to die of the disease even when corrected for stage, tumor characteristics, and age. In this issue...
Issue Information - Ed Board: from Cancer via ola Kala on Inoreader via IFTTT
Oncologic reconstruction of the hand and upper extremity: Maximizing functional outcomes: Upper extremity malignancies have the potential to create significant functional impairment, and as such represent an opportunity for collaborative reconstruction to minimize potential morbidity. Given the increased...
The impact of the revolution in hepatitis C treatment on hepatocellular carcinoma: Treatment with direct-acting anitiviral agents has revolutionized the treatment of chronic HCV infection. In the near future, these novel therapies will have a profound impact on HCV prevalence and HCV-induced carcinogenesis....
Issue Information - TOC: from Cancer via ola Kala on Inoreader via IFTTT
State-of-the-art reconstruction of midface and facial deformities: Oncologic resection involving the midface results in potentially disfiguring and challenging defects for the reconstructive surgeon. As with any defect, restoration of form and function is critical, but is particularly difficult in the...
Different Prognostic Roles Of Tumor Suppressor Gene BAP1 In Cancer: A Systematic Review With Meta-Analysis: ABSTRACT Biallelic inactivation of the tumor suppressor gene BRCA1-associated protein 1 (BAP1) has been demonstrated in several cancers, but its prognostic role has not been completely explained....
Epigenetic Regulation of SMARCB1 by miR-206, -381 and -671-5p is Evident in a Variety of SMARCB1 Immunonegative Soft Tissue Sarcomas, while miR-765 Appears Specific for Epithelioid Sarcoma. A miRNA Study of 223 Soft Tissue Sarcomas: Abstract Complete/partial loss of SMARCB1 nuclear-immunopositivity...
Use, complications, and costs of stereotactic body radiotherapy for localized prostate cancer: BACKGROUND Stereotactic body radiotherapy (SBRT) for localized prostate cancer has potential advantages over traditional radiotherapies. Herein, the authors compared national trends in use, complications,...
The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition: Summary We have previously shown that the insulinotropic imidazoline compound RX871024 induces death of insulinoma MIN6 cells, an effect involving stimulation of c-Jun N-terminal...
Pharmacokinetics and excretion of 14 C-omacetaxine in patients with advanced solid tumors: Summary Background Omacetaxine mepesuccinate is indicated in adults with chronic myeloid leukemia resistant and/or intolerant to ≥ 2 tyrosine kinase inhibitor treatments. This phase I study assessed the disposition,...
The Pattern of Use of Hypofractionated Radiation Therapy for Early Stage Breast Cancer in New South Wales, Australia, 2008-2012: Publication date: Available online 24 May 2016Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Geoff P. Delaney, Senthilkumar Gandhidasan, Richard...
A Phase I Study of Stereotactic Body Radiation Therapy Dose Escalation for Borderline Resectable Pancreatic Cancer following modified FOLFIRINOX: Publication date: Available online 24 May 2016Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Walid L. Shaib, Natalyn Hawk,...
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