Publication date: Available online 19 May 2016
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Bertha Beatriz Montaño-Velázquez, Eulalia Beatriz Flores-Rojas, Francisco Javier García-Vázquez, Silvio Jurado-Hernandez, Marco Antonio Venancio Hernández, Angélica Kathya Alanis Flores, Kathrine Jáuregui-Renaud
IntroductionIn teenagers with perennial allergic rhinitis, exposure to tobacco cigarette smoke increases the count of eosinophils in the nasal mucosa the recruitment of eosinophils arises from the combined action of a number of cellular and molecular signals, including eotaxina.ObjectiveTo assess the effect of exposure to tobacco cigarette smoke on the count of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa of children and teenagers with perennial allergic rhinitis.MethodsIn a cross-sectional study, forty-four patients were evaluated (aged 7–19 years old): 22 with and 22 with no exposure to tobacco cigarette smoke. After replying to 2 validated questionnaires, on Asthma and Allergies in Childhood and on the severity of nasal symptoms, nasal mucosal samples were obtained by scraping the middle one-third of the inferior turbinates. Then counts of immunoreactive cells to eotaxin-1 and eosinophils were assessed by immunohistochemistry.ResultsPatients with exposure to tobacco cigarette smoke showed higher cell counts of both eotaxin-1 and eosinophils than patients with no exposure to the smoke, with no correlation between the two variables. However, both counts, of eotaxin-1 and eosinophils, were related to the cotinine/creatinine ratio.ConclusionsExposure to tobacco cigarette smoke can increase eotaxin-1 and the count of eosinophils in the nasal mucosa of young patients with perennial allergic rhinitis.
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Bertha Beatriz Montaño-Velázquez, Eulalia Beatriz Flores-Rojas, Francisco Javier García-Vázquez, Silvio Jurado-Hernandez, Marco Antonio Venancio Hernández, Angélica Kathya Alanis Flores, Kathrine Jáuregui-Renaud
IntroductionIn teenagers with perennial allergic rhinitis, exposure to tobacco cigarette smoke increases the count of eosinophils in the nasal mucosa the recruitment of eosinophils arises from the combined action of a number of cellular and molecular signals, including eotaxina.ObjectiveTo assess the effect of exposure to tobacco cigarette smoke on the count of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa of children and teenagers with perennial allergic rhinitis.MethodsIn a cross-sectional study, forty-four patients were evaluated (aged 7–19 years old): 22 with and 22 with no exposure to tobacco cigarette smoke. After replying to 2 validated questionnaires, on Asthma and Allergies in Childhood and on the severity of nasal symptoms, nasal mucosal samples were obtained by scraping the middle one-third of the inferior turbinates. Then counts of immunoreactive cells to eotaxin-1 and eosinophils were assessed by immunohistochemistry.ResultsPatients with exposure to tobacco cigarette smoke showed higher cell counts of both eotaxin-1 and eosinophils than patients with no exposure to the smoke, with no correlation between the two variables. However, both counts, of eotaxin-1 and eosinophils, were related to the cotinine/creatinine ratio.ConclusionsExposure to tobacco cigarette smoke can increase eotaxin-1 and the count of eosinophils in the nasal mucosa of young patients with perennial allergic rhinitis.
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